p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression

Mutations in the TP53 gene and microenvironmentally driven activation of hypoxia-inducible factor-1 (HIF-1) typically occur in later stages of tumorigenesis. An ongoing challenge is the identification of molecular determinants of advanced cancer pathogenesis to design alternative last-line therapeut...

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Detalles Bibliográficos
Autores principales: Amelio, Ivano, Mancini, Mara, Petrova, Varvara, Cairns, Rob A., Vikhreva, Polina, Nicolai, Sara, Marini, Alberto, Antonov, Alexey A., Le Quesne, John, Baena Acevedo, Juvenal D., Dudek, Kate, Sozzi, Gabriella, Pastorino, Ugo, Knight, Richard A., Mak, Tak W., Melino, Gerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243248/
https://www.ncbi.nlm.nih.gov/pubmed/30381462
http://dx.doi.org/10.1073/pnas.1808314115

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