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Primary phosphaturic mesenchymal tumour of the lumbar spine: utility of (68)Ga-DOTATOC PET/CT findings

Primary phosphaturic mesenchymal tumours (PMTs) frequently occur in the soft tissue or bone, but rarely in the spine. The majority of patients experience long-term ostalgia and recurrent fractures. Detection of PMT can be challenging, but the clinical symptoms dramatically improve after removal of t...

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Autores principales: Maehara, Junki, Yamashita, Koji, Hiwatashi, Akio, Togao, Osamu, Kikuchi, Kazufumi, Matsumoto, Yoshihiro, Iura, Kunio, Oda, Yoshinao, Ichino, Isao, Nakamoto, Yuji, Honda, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243314/
https://www.ncbi.nlm.nih.gov/pubmed/30460030
http://dx.doi.org/10.1259/bjrcr.20150497
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author Maehara, Junki
Yamashita, Koji
Hiwatashi, Akio
Togao, Osamu
Kikuchi, Kazufumi
Matsumoto, Yoshihiro
Iura, Kunio
Oda, Yoshinao
Ichino, Isao
Nakamoto, Yuji
Honda, Hiroshi
author_facet Maehara, Junki
Yamashita, Koji
Hiwatashi, Akio
Togao, Osamu
Kikuchi, Kazufumi
Matsumoto, Yoshihiro
Iura, Kunio
Oda, Yoshinao
Ichino, Isao
Nakamoto, Yuji
Honda, Hiroshi
author_sort Maehara, Junki
collection PubMed
description Primary phosphaturic mesenchymal tumours (PMTs) frequently occur in the soft tissue or bone, but rarely in the spine. The majority of patients experience long-term ostalgia and recurrent fractures. Detection of PMT can be challenging, but the clinical symptoms dramatically improve after removal of the tumour.Wepresent a case of primary PMT in the lumbar spine. CT scan showed a low-density tumour with a well-defined sclerotic margin in the L5 vertebra. MRI revealed a hypointense tumour on T(2) weighted imaging and heterogeneous enhancement. (68)Ga-labelled 1,4,7,10-tetraazacyclododecane-N,N′,N″, N‴-tetraacetic acid-D-Phe1-Tyr3-octreotide ((68)Ga-DOTATOC) positron emission tomography/CT scan demonstrated intense focal uptake within the tumour. Histologically, proliferation of oval to short spindle-shaped cells with fibrocollagenous stroma, abundant various-sized vessels, microcysts and thickened anastomosed bone trabeculae were seen. Mitotic figures were rarely seen. Immunohistochemically, the tumour cells were focally positive for fibroblast growth factor 23. The imaging findings in the current case are in accordance with the histological features. Among them, (68)Ga-DOTATOC positron emission tomography/CT scan for somatostatin receptor imaging provides valuable information for determining PMT localization and characterization.
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spelling pubmed-62433142018-11-20 Primary phosphaturic mesenchymal tumour of the lumbar spine: utility of (68)Ga-DOTATOC PET/CT findings Maehara, Junki Yamashita, Koji Hiwatashi, Akio Togao, Osamu Kikuchi, Kazufumi Matsumoto, Yoshihiro Iura, Kunio Oda, Yoshinao Ichino, Isao Nakamoto, Yuji Honda, Hiroshi BJR Case Rep Case Report Primary phosphaturic mesenchymal tumours (PMTs) frequently occur in the soft tissue or bone, but rarely in the spine. The majority of patients experience long-term ostalgia and recurrent fractures. Detection of PMT can be challenging, but the clinical symptoms dramatically improve after removal of the tumour.Wepresent a case of primary PMT in the lumbar spine. CT scan showed a low-density tumour with a well-defined sclerotic margin in the L5 vertebra. MRI revealed a hypointense tumour on T(2) weighted imaging and heterogeneous enhancement. (68)Ga-labelled 1,4,7,10-tetraazacyclododecane-N,N′,N″, N‴-tetraacetic acid-D-Phe1-Tyr3-octreotide ((68)Ga-DOTATOC) positron emission tomography/CT scan demonstrated intense focal uptake within the tumour. Histologically, proliferation of oval to short spindle-shaped cells with fibrocollagenous stroma, abundant various-sized vessels, microcysts and thickened anastomosed bone trabeculae were seen. Mitotic figures were rarely seen. Immunohistochemically, the tumour cells were focally positive for fibroblast growth factor 23. The imaging findings in the current case are in accordance with the histological features. Among them, (68)Ga-DOTATOC positron emission tomography/CT scan for somatostatin receptor imaging provides valuable information for determining PMT localization and characterization. The British Institute of Radiology 2016-11-02 /pmc/articles/PMC6243314/ /pubmed/30460030 http://dx.doi.org/10.1259/bjrcr.20150497 Text en © 2016 The Authors. Published by the British Institute of Radiology http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Report
Maehara, Junki
Yamashita, Koji
Hiwatashi, Akio
Togao, Osamu
Kikuchi, Kazufumi
Matsumoto, Yoshihiro
Iura, Kunio
Oda, Yoshinao
Ichino, Isao
Nakamoto, Yuji
Honda, Hiroshi
Primary phosphaturic mesenchymal tumour of the lumbar spine: utility of (68)Ga-DOTATOC PET/CT findings
title Primary phosphaturic mesenchymal tumour of the lumbar spine: utility of (68)Ga-DOTATOC PET/CT findings
title_full Primary phosphaturic mesenchymal tumour of the lumbar spine: utility of (68)Ga-DOTATOC PET/CT findings
title_fullStr Primary phosphaturic mesenchymal tumour of the lumbar spine: utility of (68)Ga-DOTATOC PET/CT findings
title_full_unstemmed Primary phosphaturic mesenchymal tumour of the lumbar spine: utility of (68)Ga-DOTATOC PET/CT findings
title_short Primary phosphaturic mesenchymal tumour of the lumbar spine: utility of (68)Ga-DOTATOC PET/CT findings
title_sort primary phosphaturic mesenchymal tumour of the lumbar spine: utility of (68)ga-dotatoc pet/ct findings
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243314/
https://www.ncbi.nlm.nih.gov/pubmed/30460030
http://dx.doi.org/10.1259/bjrcr.20150497
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