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DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38
DNA methylation plays an essential role in the control of gene expression during early stages of development as well as in disease. Although many transcription factors are sensitive to this modification of the DNA, we still do not clearly understand how it contributes to the establishment of proper...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243405/ https://www.ncbi.nlm.nih.gov/pubmed/30480223 http://dx.doi.org/10.1177/2516865718811117 |
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author | de Dieuleveult, Maud Miotto, Benoit |
author_facet | de Dieuleveult, Maud Miotto, Benoit |
author_sort | de Dieuleveult, Maud |
collection | PubMed |
description | DNA methylation plays an essential role in the control of gene expression during early stages of development as well as in disease. Although many transcription factors are sensitive to this modification of the DNA, we still do not clearly understand how it contributes to the establishment of proper gene expression patterns. We discuss here the recent findings regarding the biological and molecular function(s) of the transcription factor ZBTB38 that binds methylated DNA sequences in vitro and in cells. We speculate how these findings may help understand the role of DNA methylation and DNA methylation–sensitive transcription factors in mammalian cells. |
format | Online Article Text |
id | pubmed-6243405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-62434052018-11-26 DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38 de Dieuleveult, Maud Miotto, Benoit Epigenet Insights Commentary DNA methylation plays an essential role in the control of gene expression during early stages of development as well as in disease. Although many transcription factors are sensitive to this modification of the DNA, we still do not clearly understand how it contributes to the establishment of proper gene expression patterns. We discuss here the recent findings regarding the biological and molecular function(s) of the transcription factor ZBTB38 that binds methylated DNA sequences in vitro and in cells. We speculate how these findings may help understand the role of DNA methylation and DNA methylation–sensitive transcription factors in mammalian cells. SAGE Publications 2018-11-19 /pmc/articles/PMC6243405/ /pubmed/30480223 http://dx.doi.org/10.1177/2516865718811117 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Commentary de Dieuleveult, Maud Miotto, Benoit DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38 |
title | DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38 |
title_full | DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38 |
title_fullStr | DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38 |
title_full_unstemmed | DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38 |
title_short | DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38 |
title_sort | dna methylation and chromatin: role(s) of methyl-cpg-binding protein zbtb38 |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243405/ https://www.ncbi.nlm.nih.gov/pubmed/30480223 http://dx.doi.org/10.1177/2516865718811117 |
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