MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers

Since “Warburg effect” has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs’ energy metabolic...

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Detalles Bibliográficos
Autores principales: Ye, Jin, Zou, Manman, Li, Pei, Liu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243412/
https://www.ncbi.nlm.nih.gov/pubmed/30444190
http://dx.doi.org/10.1177/1533033818805997
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author Ye, Jin
Zou, Manman
Li, Pei
Liu, Hui
author_facet Ye, Jin
Zou, Manman
Li, Pei
Liu, Hui
author_sort Ye, Jin
collection PubMed
description Since “Warburg effect” has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs’ energy metabolic role in chemoresistance has been probed recently. In this review, we summarize 5 microRNAs in regulating glucose and lipid metabolism and other energy metabolism. They partially modulate chemoresistance to cancer treatments. Furthermore, we discuss the great therapeutic potential of metabolism-related microRNAs in novel combinatorial means to treat human cancers.
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spelling pubmed-62434122018-11-26 MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers Ye, Jin Zou, Manman Li, Pei Liu, Hui Technol Cancer Res Treat Review Since “Warburg effect” has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs’ energy metabolic role in chemoresistance has been probed recently. In this review, we summarize 5 microRNAs in regulating glucose and lipid metabolism and other energy metabolism. They partially modulate chemoresistance to cancer treatments. Furthermore, we discuss the great therapeutic potential of metabolism-related microRNAs in novel combinatorial means to treat human cancers. SAGE Publications 2018-11-16 /pmc/articles/PMC6243412/ /pubmed/30444190 http://dx.doi.org/10.1177/1533033818805997 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Ye, Jin
Zou, Manman
Li, Pei
Liu, Hui
MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers
title MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers
title_full MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers
title_fullStr MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers
title_full_unstemmed MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers
title_short MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers
title_sort microrna regulation of energy metabolism to induce chemoresistance in cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243412/
https://www.ncbi.nlm.nih.gov/pubmed/30444190
http://dx.doi.org/10.1177/1533033818805997
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