Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists

We report a case of prenatal exposure to angiotensin II receptor antagonists (ARA II) from the beginning of pregnancy in a patient with a hypokinetic dilated cardiomyopathy. This case report emphasizes the fetal renal impact of prolonged intrauterine exposure to renin-angiotensin system (RAS) blocke...

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Autores principales: Lallemant, Marine, Prévost, Sarah, Nobili, François, Riethmuller, Didier, Ramanah, Rajeev, Seronde, Marie-France, Mottet, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243420/
https://www.ncbi.nlm.nih.gov/pubmed/30394825
http://dx.doi.org/10.1177/1470320318810940
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author Lallemant, Marine
Prévost, Sarah
Nobili, François
Riethmuller, Didier
Ramanah, Rajeev
Seronde, Marie-France
Mottet, Nicolas
author_facet Lallemant, Marine
Prévost, Sarah
Nobili, François
Riethmuller, Didier
Ramanah, Rajeev
Seronde, Marie-France
Mottet, Nicolas
author_sort Lallemant, Marine
collection PubMed
description We report a case of prenatal exposure to angiotensin II receptor antagonists (ARA II) from the beginning of pregnancy in a patient with a hypokinetic dilated cardiomyopathy. This case report emphasizes the fetal renal impact of prolonged intrauterine exposure to renin-angiotensin system (RAS) blockers, and highlights that this exposure can cause severe prenatal hypocalvaria. This delayed ossification can be reversible after birth, but the presence of anhydramnios indicates an early and irreversible block of RAS blockers in the fetus that is responsible for fetal kidney development abnormalities. This association carries a high risk of neonatal death. Prolonged exposure to ARA II or other RAS blockers remains prohibited throughout pregnancy.
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spelling pubmed-62434202018-11-26 Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists Lallemant, Marine Prévost, Sarah Nobili, François Riethmuller, Didier Ramanah, Rajeev Seronde, Marie-France Mottet, Nicolas J Renin Angiotensin Aldosterone Syst Case Report We report a case of prenatal exposure to angiotensin II receptor antagonists (ARA II) from the beginning of pregnancy in a patient with a hypokinetic dilated cardiomyopathy. This case report emphasizes the fetal renal impact of prolonged intrauterine exposure to renin-angiotensin system (RAS) blockers, and highlights that this exposure can cause severe prenatal hypocalvaria. This delayed ossification can be reversible after birth, but the presence of anhydramnios indicates an early and irreversible block of RAS blockers in the fetus that is responsible for fetal kidney development abnormalities. This association carries a high risk of neonatal death. Prolonged exposure to ARA II or other RAS blockers remains prohibited throughout pregnancy. SAGE Publications 2018-11-04 /pmc/articles/PMC6243420/ /pubmed/30394825 http://dx.doi.org/10.1177/1470320318810940 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Lallemant, Marine
Prévost, Sarah
Nobili, François
Riethmuller, Didier
Ramanah, Rajeev
Seronde, Marie-France
Mottet, Nicolas
Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists
title Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists
title_full Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists
title_fullStr Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists
title_full_unstemmed Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists
title_short Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists
title_sort prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin ii receptor antagonists
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243420/
https://www.ncbi.nlm.nih.gov/pubmed/30394825
http://dx.doi.org/10.1177/1470320318810940
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