Regiocontrol in the cobalt-catalyzed hydrosilylation of alkynes

Hydrofunctionalizations of unsaturated hydrocarbons are key strategies for the synthesis of functionalized building blocks. Here, we report highly versatile cobalt-catalyzed hydrosilylations of alkynes that operate with minute amounts of the inexpensive, bench-stable pre-catalyst Co(OAc)(2)·4H(2)O u...

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Detalles Bibliográficos
Autores principales: Wu, Guojiao, Chakraborty, Uttam, Jacobi von Wangelin, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243675/
https://www.ncbi.nlm.nih.gov/pubmed/30310911
http://dx.doi.org/10.1039/c8cc07267a
Descripción
Sumario:Hydrofunctionalizations of unsaturated hydrocarbons are key strategies for the synthesis of functionalized building blocks. Here, we report highly versatile cobalt-catalyzed hydrosilylations of alkynes that operate with minute amounts of the inexpensive, bench-stable pre-catalyst Co(OAc)(2)·4H(2)O under mild conditions (0.1–1 mol%, THF, r.t., 1 h). Near-perfect regiocontrol/stereocontrol was induced by the choice of the ligand: bidentate phosphines afforded (E)-β-vinylsilanes; α-vinylsilanes formed with bipyridine ligands.

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