CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident fro...

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Autores principales: Hems, Edward S., Wagstaff, Ben A., Saalbach, Gerhard, Field, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243676/
https://www.ncbi.nlm.nih.gov/pubmed/30311608
http://dx.doi.org/10.1039/c8cc05113e
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author Hems, Edward S.
Wagstaff, Ben A.
Saalbach, Gerhard
Field, Robert A.
author_facet Hems, Edward S.
Wagstaff, Ben A.
Saalbach, Gerhard
Field, Robert A.
author_sort Hems, Edward S.
collection PubMed
description In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.
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spelling pubmed-62436762018-12-12 CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins Hems, Edward S. Wagstaff, Ben A. Saalbach, Gerhard Field, Robert A. Chem Commun (Camb) Chemistry In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins. Royal Society of Chemistry 2018-11-07 2018-10-12 /pmc/articles/PMC6243676/ /pubmed/30311608 http://dx.doi.org/10.1039/c8cc05113e Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Hems, Edward S.
Wagstaff, Ben A.
Saalbach, Gerhard
Field, Robert A.
CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins
title CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins
title_full CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins
title_fullStr CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins
title_full_unstemmed CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins
title_short CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins
title_sort cuaac click chemistry for the enhanced detection of novel alkyne-based natural product toxins
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243676/
https://www.ncbi.nlm.nih.gov/pubmed/30311608
http://dx.doi.org/10.1039/c8cc05113e
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