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Cytology of the fallopian tube: A screening model for high-grade serous carcinoma

Ovarian cancer is a heterogeneous disease having the highest gynecologic fatality in the United States with a 5-year survival rate of 46.5%. Poor overall prognosis is mostly attributed to inadequate screening tools, and the majority of diagnoses occur at late stages of the disease. Due to genetic an...

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Autores principales: Dhanani, Maya, Nassar, Aziza, Charles, Mélissa S., Dinh, Tri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243852/
https://www.ncbi.nlm.nih.gov/pubmed/30534183
http://dx.doi.org/10.4103/cytojournal.cytojournal_58_17
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author Dhanani, Maya
Nassar, Aziza
Charles, Mélissa S.
Dinh, Tri
author_facet Dhanani, Maya
Nassar, Aziza
Charles, Mélissa S.
Dinh, Tri
author_sort Dhanani, Maya
collection PubMed
description Ovarian cancer is a heterogeneous disease having the highest gynecologic fatality in the United States with a 5-year survival rate of 46.5%. Poor overall prognosis is mostly attributed to inadequate screening tools, and the majority of diagnoses occur at late stages of the disease. Due to genetic and biological underpinnings, ovarian high-grade serous carcinomas (HGSC) have etiologic evidence in the distal fallopian tube. Fallopian tube screening modalities are aggressively investigated, but few describe cytological characteristics of benign tubal specimens to help in the comparative detection of HGSC precursor cells. Here, we describe fimbrial cytomorphological and nuclear features of tubal specimens (n = 75) from patients clinically indicated for salpingectomy, bilateral or unilateral salpingo-oophorectomy, and hysterectomies for any diagnosis other than ovarian or peritoneal cancer. Fallopian tube histology was used as the diagnostic reference. A total of 75 samples had benign diagnoses. The benign cytological characteristics of fimbrial tubal specimens included ciliated cells in clustered arrangements with mild nuclear membrane irregularity, mild anisonucleosis, round and/or oval nuclei, hyperchromatic chromatin, and mild nuclear membrane irregularity. In contrast, none of the cytology samples had spindle-shaped nuclei, significantly marked anisonucleosis (n = 1), nor had hypochromasia as a characteristic feature. These cytological characteristics could be a potential area of distinction from HGSC precursor cells. Our study establishes cytomorphological characteristics of nonmalignant tubal cells which help underscore the importance of distinguishing malignant HGSC precursors through fimbrial brush sampling in minimally invasive approach.
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spelling pubmed-62438522018-12-10 Cytology of the fallopian tube: A screening model for high-grade serous carcinoma Dhanani, Maya Nassar, Aziza Charles, Mélissa S. Dinh, Tri Cytojournal Research Article Ovarian cancer is a heterogeneous disease having the highest gynecologic fatality in the United States with a 5-year survival rate of 46.5%. Poor overall prognosis is mostly attributed to inadequate screening tools, and the majority of diagnoses occur at late stages of the disease. Due to genetic and biological underpinnings, ovarian high-grade serous carcinomas (HGSC) have etiologic evidence in the distal fallopian tube. Fallopian tube screening modalities are aggressively investigated, but few describe cytological characteristics of benign tubal specimens to help in the comparative detection of HGSC precursor cells. Here, we describe fimbrial cytomorphological and nuclear features of tubal specimens (n = 75) from patients clinically indicated for salpingectomy, bilateral or unilateral salpingo-oophorectomy, and hysterectomies for any diagnosis other than ovarian or peritoneal cancer. Fallopian tube histology was used as the diagnostic reference. A total of 75 samples had benign diagnoses. The benign cytological characteristics of fimbrial tubal specimens included ciliated cells in clustered arrangements with mild nuclear membrane irregularity, mild anisonucleosis, round and/or oval nuclei, hyperchromatic chromatin, and mild nuclear membrane irregularity. In contrast, none of the cytology samples had spindle-shaped nuclei, significantly marked anisonucleosis (n = 1), nor had hypochromasia as a characteristic feature. These cytological characteristics could be a potential area of distinction from HGSC precursor cells. Our study establishes cytomorphological characteristics of nonmalignant tubal cells which help underscore the importance of distinguishing malignant HGSC precursors through fimbrial brush sampling in minimally invasive approach. Medknow Publications & Media Pvt Ltd 2018-11-12 /pmc/articles/PMC6243852/ /pubmed/30534183 http://dx.doi.org/10.4103/cytojournal.cytojournal_58_17 Text en Copyright: © 2018 Dhanani, et al.; Licensee Cytopathology Foundation Inc. http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Research Article
Dhanani, Maya
Nassar, Aziza
Charles, Mélissa S.
Dinh, Tri
Cytology of the fallopian tube: A screening model for high-grade serous carcinoma
title Cytology of the fallopian tube: A screening model for high-grade serous carcinoma
title_full Cytology of the fallopian tube: A screening model for high-grade serous carcinoma
title_fullStr Cytology of the fallopian tube: A screening model for high-grade serous carcinoma
title_full_unstemmed Cytology of the fallopian tube: A screening model for high-grade serous carcinoma
title_short Cytology of the fallopian tube: A screening model for high-grade serous carcinoma
title_sort cytology of the fallopian tube: a screening model for high-grade serous carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243852/
https://www.ncbi.nlm.nih.gov/pubmed/30534183
http://dx.doi.org/10.4103/cytojournal.cytojournal_58_17
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