Severe de novo Ulcerative Colitis following Ixekizumab Therapy

Ixekizumab is a selective monoclonal antibody targeting interleukin-17A, approved for the treatment of chronic plaque psoriasis. It has rarely been associated with inflammatory bowel disease (IBD) in randomized trials only. We report a unique case of severe new-onset ulcerative colitis in a young ma...

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Autores principales: Philipose, Jobin, Ahmed, Moiz, Idiculla, Pretty S., Mulrooney, Stephen M., Gumaste, Vivek V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244035/
https://www.ncbi.nlm.nih.gov/pubmed/30483039
http://dx.doi.org/10.1159/000493922
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author Philipose, Jobin
Ahmed, Moiz
Idiculla, Pretty S.
Mulrooney, Stephen M.
Gumaste, Vivek V.
author_facet Philipose, Jobin
Ahmed, Moiz
Idiculla, Pretty S.
Mulrooney, Stephen M.
Gumaste, Vivek V.
author_sort Philipose, Jobin
collection PubMed
description Ixekizumab is a selective monoclonal antibody targeting interleukin-17A, approved for the treatment of chronic plaque psoriasis. It has rarely been associated with inflammatory bowel disease (IBD) in randomized trials only. We report a unique case of severe new-onset ulcerative colitis in a young male complicated by cytomegalovirus infection who was on ixekizumab therapy for plaque psoriasis. We recommend that clinicians should exercise caution before prescribing ixekizumab as it seems to induce and exacerbate IBD.
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spelling pubmed-62440352018-11-27 Severe de novo Ulcerative Colitis following Ixekizumab Therapy Philipose, Jobin Ahmed, Moiz Idiculla, Pretty S. Mulrooney, Stephen M. Gumaste, Vivek V. Case Rep Gastroenterol Single Case Ixekizumab is a selective monoclonal antibody targeting interleukin-17A, approved for the treatment of chronic plaque psoriasis. It has rarely been associated with inflammatory bowel disease (IBD) in randomized trials only. We report a unique case of severe new-onset ulcerative colitis in a young male complicated by cytomegalovirus infection who was on ixekizumab therapy for plaque psoriasis. We recommend that clinicians should exercise caution before prescribing ixekizumab as it seems to induce and exacerbate IBD. S. Karger AG 2018-10-17 /pmc/articles/PMC6244035/ /pubmed/30483039 http://dx.doi.org/10.1159/000493922 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Philipose, Jobin
Ahmed, Moiz
Idiculla, Pretty S.
Mulrooney, Stephen M.
Gumaste, Vivek V.
Severe de novo Ulcerative Colitis following Ixekizumab Therapy
title Severe de novo Ulcerative Colitis following Ixekizumab Therapy
title_full Severe de novo Ulcerative Colitis following Ixekizumab Therapy
title_fullStr Severe de novo Ulcerative Colitis following Ixekizumab Therapy
title_full_unstemmed Severe de novo Ulcerative Colitis following Ixekizumab Therapy
title_short Severe de novo Ulcerative Colitis following Ixekizumab Therapy
title_sort severe de novo ulcerative colitis following ixekizumab therapy
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244035/
https://www.ncbi.nlm.nih.gov/pubmed/30483039
http://dx.doi.org/10.1159/000493922
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AT mulrooneystephenm severedenovoulcerativecolitisfollowingixekizumabtherapy
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