Vasoinhibin comprises a three-helix bundle and its antiangiogenic domain is located within the first 79 residues

Vasoinhibin belongs to a family of angiogenesis inhibitors generated when the fourth α-helix (H4) of the hormone prolactin (PRL) is removed by specific proteolytic cleavage. The antiangiogenic properties are absent in uncleaved PRL, indicating that conformational changes create a new bioactive domai...

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Detalles Bibliográficos
Autores principales: Robles, Juan Pablo, Zamora, Magdalena, Velasco-Bolom, José Luis, Tovar, Miriam, Garduño-Juárez, Ramón, Bertsch, Thomas, Martínez de la Escalera, Gonzalo, Triebel, Jakob, Clapp, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244167/
https://www.ncbi.nlm.nih.gov/pubmed/30459448
http://dx.doi.org/10.1038/s41598-018-35383-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244167/
https://www.ncbi.nlm.nih.gov/pubmed/30459448
http://dx.doi.org/10.1038/s41598-018-35383-7

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