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Vasoinhibin comprises a three-helix bundle and its antiangiogenic domain is located within the first 79 residues
Vasoinhibin belongs to a family of angiogenesis inhibitors generated when the fourth α-helix (H4) of the hormone prolactin (PRL) is removed by specific proteolytic cleavage. The antiangiogenic properties are absent in uncleaved PRL, indicating that conformational changes create a new bioactive domai...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244167/ https://www.ncbi.nlm.nih.gov/pubmed/30459448 http://dx.doi.org/10.1038/s41598-018-35383-7 |