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Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors

Novel 2- or 4-phosphonated 13α-estrone derivatives were synthesized via the Hirao reaction. Bromo regioisomers (2- or 4-) of 13α-estrone and its 3-benzyl or 3-methyl ether were reacted with diethyl phosphite or diphenylphosphine oxide using Pd(PPh(3))(4) as catalyst under microwave irradiation. The...

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Detalles Bibliográficos
Autores principales:	Jójárt, Rebeka, Pécsy, Szabolcs, Keglevich, György, Szécsi, Mihály, Rigó, Réka, Özvegy-Laczka, Csilla, Kecskeméti, Gábor, Mernyák, Erzsébet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2018
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244214/ https://www.ncbi.nlm.nih.gov/pubmed/30498534 http://dx.doi.org/10.3762/bjoc.14.262

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