Cargando…

The paracrine effects of human induced pluripotent stem cells promote bone-like structures via the upregulation of BMP expression in a mouse ectopic model

Use of human induced pluripotent stem cells (h-iPSCs) for bone tissue engineering is most appealing, because h-iPSCs are an inexhaustible source of osteocompetent cells. The present study investigated the contribution of undifferentiated h-iPSCs and elucidated aspects of the underlying mechanism(s)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oudina, Karim, Paquet, Joseph, Moya, Adrien, Massourides, Emmanuelle, Bensidhoum, Morad, Larochette, Nathanaël, Deschepper, Mickael, Pinset, Christian, Petite, Hervé
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244408/ https://www.ncbi.nlm.nih.gov/pubmed/30459360 http://dx.doi.org/10.1038/s41598-018-35546-6

Ejemplares similares

Survival and function of mesenchymal stem cells (MSCs) depend on glucose to overcome exposure to long-term, severe and continuous hypoxia
por: Deschepper, M, et al.
Publicado: (2011)

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
por: Manassero, Mathieu, et al.
Publicado: (2016)

Experimental Type 2 Diabetes Differently Impacts on the Select Functions of Bone Marrow-Derived Multipotent Stromal Cells
por: Ribot, Jonathan, et al.
Publicado: (2021)

Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells
por: Massouridès, Emmanuelle, et al.
Publicado: (2015)

Myogenesis modelled by human pluripotent stem cells: a multi‐omic study of Duchenne myopathy early onset
por: Mournetas, Virginie, et al.
Publicado: (2021)

Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids
por: Jennissen, Herbert P.
Publicado: (2023)

Efficient autocrine and paracrine signaling explain the osteogenic superiority of transgenic BMP-2 over rhBMP-2
por: Atasoy-Zeybek, Aysegul, et al.
Publicado: (2023)

Comparability of automated human induced pluripotent stem cell culture: a pilot study
por: Archibald, Peter R. T., et al.
Publicado: (2016)

A comparative study of tissue-engineered constructs from Acropora and Porites coral in a large animal bone defect model
por: Decambron, A., et al.
Publicado: (2017)

The Paracrine Effect of Hyaluronic Acid-Treated Endothelial Cells Promotes BMP-2-Mediated Osteogenesis
por: Tong, Xiaojie, et al.
Publicado: (2023)

Type 2 diabetes alters mesenchymal stem cell secretome composition and angiogenic properties
por: Ribot, Jonathan, et al.
Publicado: (2016)

In vivo dynamic analysis of BMP-2-induced ectopic bone formation
por: Hashimoto, Kunihiko, et al.
Publicado: (2020)

Hepatic SATB1 induces paracrine activation of hepatic stellate cells and is upregulated by HBx
por: Gong, Jin, et al.
Publicado: (2016)

Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia
por: Tillet, Emmanuelle, et al.
Publicado: (2015)

Slow diffusion on the monolayer culture enhances auto/paracrine effects of Noggin in differentiation of human iPS cells induced by BMP
por: Nakatani, Eri, et al.
Publicado: (2021)

Effect of Dual Treatment with SDF-1 and BMP-2 on Ectopic and Orthotopic Bone Formation
por: Lee, Chang-Hwan, et al.
Publicado: (2015)

Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity
por: Prados, Belén, et al.
Publicado: (2018)

A Cyclic BMP-2 Peptide Upregulates BMP-2 Protein-Induced Cell Signaling in Myogenic Cells
por: Gudivada, Vijaya Narasimha, et al.
Publicado: (2021)

Correlation between skin and bone parameters in women with postmenopausal osteoporosis: A systematic review
por: Aurégan, Jean-Charles, et al.
Publicado: (2018)

Identification of BMP and Activin Membrane-Bound Inhibitor (BAMBI) as a Potent Negative Regulator of Adipogenesis and Modulator of Autocrine/Paracrine Adipogenic Factors
por: Luo, Xiao, et al.
Publicado: (2012)

Author Correction: Hepatic SATB1 induces paracrine activation of hepatic stellate cells and is upregulated by HBx
por: Gong, Jin, et al.
Publicado: (2021)

Microcomputed tomography of the femur of diabetic rats: alterations of trabecular and cortical bone microarchitecture and vasculature—a feasibility study
por: Zeitoun, David, et al.
Publicado: (2019)

Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells
por: Constantinou, Chrystalla, et al.
Publicado: (2020)

MYC promotes fibroblast osteogenesis by regulating ALP and BMP2 to participate in ectopic ossification of ankylosing spondylitis
por: Jin, Qianmei, et al.
Publicado: (2023)

Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation
por: Zunich, Samantha M, et al.
Publicado: (2012)

Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4
por: Gallardo-Vara, Eunate, et al.
Publicado: (2020)

Brd4 Inactivation Increases Adenoviral Delivery of BMP2 for Paracrine Stimulation of Osteogenic Differentiation as a Gene Therapeutic Concept to Enhance Bone Healing
por: Paradise, Christopher R, et al.
Publicado: (2021)

Preventive Moderate Continuous Running-Exercise Conditioning Improves the Healing of Non-Critical Size Bone Defects in Male Wistar Rats: A Pilot Study Using µCT
por: Bourzac, Céline, et al.
Publicado: (2020)

Bapx1 upregulation is associated with ectopic mandibular cartilage development in amphibians
por: Lukas, Paul, et al.
Publicado: (2018)

FAM20A Gene Mutation: Amelogenesis or Ectopic Mineralization?
por: Lignon, Guilhem, et al.
Publicado: (2017)

Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy
por: Zhang, Yuelin, et al.
Publicado: (2015)

Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development
por: Glass, Nick R., et al.
Publicado: (2020)

Evaluation of a Thiolated Chitosan Scaffold for Local Delivery of BMP-2 for Osteogenic Differentiation and Ectopic Bone Formation
por: Bae, In-Ho, et al.
Publicado: (2013)

Efficient retina formation requires suppression of both Activin and BMP signaling pathways in pluripotent cells
por: Wong, Kimberly A., et al.
Publicado: (2015)

GPCRs in Autocrine and Paracrine Regulations
por: Tse, Lap Hang, et al.
Publicado: (2019)

Paracrine Factors in Uremic Cardiomyopathy
por: Sucharov, Carmen C.
Publicado: (2020)

Paracrine and endocrine functions of osteocytes
por: Michigami, Toshimi
Publicado: (2022)

Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45
por: Ke, Qiong, et al.
Publicado: (2017)

BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease
por: Zhang, Xiaoqing, et al.
Publicado: (2021)

Inhibition of Gap Junctional Intercellular Communication Upregulates Pluripotency Gene Expression in Endogenous Pluripotent Muse Cells
por: Hatabi, Khaled, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d3ls69dsqb4rmkjua1uu7o9o6t