Nutritional Status Differentially Alters Cytochrome P450 3A4 (CYP3A4) and Uridine 5′-Diphospho-Glucuronosyltransferase (UGT) Mediated Drug Metabolism: Effect of Short-Term Fasting and High Fat Diet on Midazolam Metabolism

BACKGROUND AND OBJECTIVES: Previous studies have shown that nutritional status can alter drug metabolism which may result in treatment failure or untoward side effects. This study assesses the effect of two nutritional conditions, short-term fasting, and a short-term high fat diet (HFD) on cytochrom...

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Detalles Bibliográficos
Autores principales: Lammers, Laureen A., Achterbergh, Roos, Romijn, Johannes A., Mathôt, Ron A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244726/
https://www.ncbi.nlm.nih.gov/pubmed/29876844
http://dx.doi.org/10.1007/s13318-018-0487-5

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