Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles

Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-aryl-butanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b.Treatment of the latter with acetonitrile afforded novel β-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the...

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Autores principales: Riyadh, Sayed M., Al-Matar, Hamad M., Elnagdi, Mohamed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244831/
https://www.ncbi.nlm.nih.gov/pubmed/19078855
http://dx.doi.org/10.3390/molecules13123140
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author Riyadh, Sayed M.
Al-Matar, Hamad M.
Elnagdi, Mohamed H.
author_facet Riyadh, Sayed M.
Al-Matar, Hamad M.
Elnagdi, Mohamed H.
author_sort Riyadh, Sayed M.
collection PubMed
description Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-aryl-butanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b.Treatment of the latter with acetonitrile afforded novel β-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively.
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spelling pubmed-62448312018-11-26 Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles Riyadh, Sayed M. Al-Matar, Hamad M. Elnagdi, Mohamed H. Molecules Article Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4-aryl-butanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b.Treatment of the latter with acetonitrile afforded novel β-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively. MDPI 2008-12-15 /pmc/articles/PMC6244831/ /pubmed/19078855 http://dx.doi.org/10.3390/molecules13123140 Text en © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Riyadh, Sayed M.
Al-Matar, Hamad M.
Elnagdi, Mohamed H.
Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles
title Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles
title_full Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles
title_fullStr Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles
title_full_unstemmed Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles
title_short Studies with β-Oxoalkanonitriles: Simple Novel Synthesis of 3-[2,6-Diaryl-4- pyridyl]-3-oxopropanenitriles
title_sort studies with β-oxoalkanonitriles: simple novel synthesis of 3-[2,6-diaryl-4- pyridyl]-3-oxopropanenitriles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244831/
https://www.ncbi.nlm.nih.gov/pubmed/19078855
http://dx.doi.org/10.3390/molecules13123140
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