Efficient and Eco-Friendly Preparation of4-Methyl-5-formyl-thiazole

4-Methyl-5-formylthiazole, an intermediate for synthesizing cefditoren pivoxil, was prepared in good yield by Pd/BaSO(4) catalyzed hydrogenation of 4-methylthiazole-5-carboxylic acid chloride. Detailed reaction conditions have been studied.

Detalles Bibliográficos
Autores principales: Bai, Nan, Sha, Yaowu, Meng, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244845/
https://www.ncbi.nlm.nih.gov/pubmed/18463596
http://dx.doi.org/10.3390/molecules13040943
Descripción
Sumario:4-Methyl-5-formylthiazole, an intermediate for synthesizing cefditoren pivoxil, was prepared in good yield by Pd/BaSO(4) catalyzed hydrogenation of 4-methylthiazole-5-carboxylic acid chloride. Detailed reaction conditions have been studied.

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