5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involve...

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Autores principales: Zhang, Ning, Yin, Ying, Xu, Sheng-Jie, Chen, Wei-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244944/
https://www.ncbi.nlm.nih.gov/pubmed/18794772
http://dx.doi.org/10.3390/molecules13081551
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author Zhang, Ning
Yin, Ying
Xu, Sheng-Jie
Chen, Wei-Shan
author_facet Zhang, Ning
Yin, Ying
Xu, Sheng-Jie
Chen, Wei-Shan
author_sort Zhang, Ning
collection PubMed
description The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.
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spelling pubmed-62449442018-11-26 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies Zhang, Ning Yin, Ying Xu, Sheng-Jie Chen, Wei-Shan Molecules Review The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described. MDPI 2008-08-05 /pmc/articles/PMC6244944/ /pubmed/18794772 http://dx.doi.org/10.3390/molecules13081551 Text en © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Zhang, Ning
Yin, Ying
Xu, Sheng-Jie
Chen, Wei-Shan
5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
title 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
title_full 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
title_fullStr 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
title_full_unstemmed 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
title_short 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
title_sort 5-fluorouracil: mechanisms of resistance and reversal strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244944/
https://www.ncbi.nlm.nih.gov/pubmed/18794772
http://dx.doi.org/10.3390/molecules13081551
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AT xushengjie 5fluorouracilmechanismsofresistanceandreversalstrategies
AT chenweishan 5fluorouracilmechanismsofresistanceandreversalstrategies

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