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Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition

INTRODUCTION: Targeted cancer therapeutics have demonstrated more limited clinical efficacy than anticipated, due to both intrinsic and acquired drug resistance. Underlying mechanisms have been largely attributed to genetic changes, but a substantial proportion of resistance observations remain unex...

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Detalles Bibliográficos
Autores principales:	Claas, Allison M., Atta, Lyla, Gordonov, Simon, Meyer, Aaron S., Lauffenburger, Douglas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244947/ https://www.ncbi.nlm.nih.gov/pubmed/30524510 http://dx.doi.org/10.1007/s12195-018-0542-y

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