Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions

2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are nota...

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Autores principales: Kuo, Chun-Wei, Wang, Chun-Chao, Kavala, Veerababurao, Yao, Ching-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244957/
https://www.ncbi.nlm.nih.gov/pubmed/18830157
http://dx.doi.org/10.3390/molecules13092313
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author Kuo, Chun-Wei
Wang, Chun-Chao
Kavala, Veerababurao
Yao, Ching-Fa
author_facet Kuo, Chun-Wei
Wang, Chun-Chao
Kavala, Veerababurao
Yao, Ching-Fa
author_sort Kuo, Chun-Wei
collection PubMed
description 2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.
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spelling pubmed-62449572018-11-30 Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions Kuo, Chun-Wei Wang, Chun-Chao Kavala, Veerababurao Yao, Ching-Fa Molecules Article 2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method. MDPI 2008-09-25 /pmc/articles/PMC6244957/ /pubmed/18830157 http://dx.doi.org/10.3390/molecules13092313 Text en © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kuo, Chun-Wei
Wang, Chun-Chao
Kavala, Veerababurao
Yao, Ching-Fa
Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions
title Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions
title_full Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions
title_fullStr Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions
title_full_unstemmed Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions
title_short Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions
title_sort efficient tct-catalyzed synthesis of 1,5-benzodiazepine derivatives under mild conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244957/
https://www.ncbi.nlm.nih.gov/pubmed/18830157
http://dx.doi.org/10.3390/molecules13092313
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AT kavalaveerababurao efficienttctcatalyzedsynthesisof15benzodiazepinederivativesundermildconditions
AT yaochingfa efficienttctcatalyzedsynthesisof15benzodiazepinederivativesundermildconditions

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