Synthesis of RP 48497, an Impurity of Eszopiclone

RP 48497 is a photodegradation product of eszopiclone, a non-benzodiazepine sedative-hypnotic used in the treatment of insomnia. We report herein the first synthesis of RP 48497 via reduction, chlorination, and recyclization of 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydropyrrolo[3,4-b]pyrazin-5-on...

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Detalles Bibliográficos
Autores principales: Sha, Yu, Zhang, Lei, Du, Gui-Jie, Ren, Jian, Cheng, Mao-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245065/
https://www.ncbi.nlm.nih.gov/pubmed/18794786
http://dx.doi.org/10.3390/molecules13081817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245065/
https://www.ncbi.nlm.nih.gov/pubmed/18794786
http://dx.doi.org/10.3390/molecules13081817

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