Cargando…

Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach

This review describes specific strategies for targeting to the central nervous system (CNS). Systemically administered drugs can reach the brain by crossing one of two physiological barriers resistant to free diffusion of most molecules from blood to CNS: the endothelial blood-brain barrier or the e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pavan, Barbara, Dalpiaz, Alessandro, Ciliberti, Nunzia, Biondi, Carla, Manfredini, Stefano, Vertuani, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2008
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245073/ https://www.ncbi.nlm.nih.gov/pubmed/18560328 http://dx.doi.org/10.3390/molecules13051035

Ejemplares similares

Conjugation, Prodrug, and Co-Administration Strategies in Support of Nanotechnologies to Improve the Therapeutic Efficacy of Phytochemicals in the Central Nervous System
por: Rassu, Giovanna, et al.
Publicado: (2023)

Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug
por: Napolitano, Carmela, et al.
Publicado: (2009)

Targeting Systems to the Brain Obtained by Merging Prodrugs, Nanoparticles, and Nasal Administration
por: Botti, Giada, et al.
Publicado: (2021)

Nose-to-Brain Delivery of Antiviral Drugs: A Way to Overcome Their Active Efflux?
por: Dalpiaz, Alessandro, et al.
Publicado: (2018)

Uptake in the Central Nervous System of Geraniol Oil Encapsulated in Chitosan Oleate Following Nasal and Oral Administration
por: Bonferoni, Maria Cristina, et al.
Publicado: (2019)

Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration
por: Ahmadi-Ashtiani, Hamid-Reza, et al.
Publicado: (2020)

Effects of Microencapsulated Ferulic Acid or Its Prodrug Methyl Ferulate on Neuroinflammation Induced by Muramyl Dipeptide
por: Botti, Giada, et al.
Publicado: (2022)

Nanomaterials for Drug Delivery to the Central Nervous System
por: Teleanu, Daniel Mihai, et al.
Publicado: (2019)

Formulation and Characterization of Native and Crosslinked Hyaluronic Acid Microspheres for Dermal Delivery of Sodium Ascorbyl Phosphate: A Comparative Study
por: Fallacara, Arianna, et al.
Publicado: (2018)

Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents
por: Prokai-Tatrai, Katalin, et al.
Publicado: (2009)

A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy
por: Prokai-Tatrai, Katalin, et al.
Publicado: (2019)

Strategies for Enhanced Drug Delivery to the Central Nervous System
por: Dwibhashyam, V. S. N. M., et al.
Publicado: (2008)

Liposomal Conjugates for Drug Delivery to the Central Nervous System
por: Helm, Frieder, et al.
Publicado: (2015)

Pathogen-inspired drug delivery to the central nervous system
por: McCall, Rebecca L, et al.
Publicado: (2014)

Hyaluronic Acid in the Third Millennium
por: Fallacara, Arianna, et al.
Publicado: (2018)

A Co-delivery System Based on a Dimeric Prodrug and Star-Shaped Polymeric Prodrug Micelles for Drug Delivery
por: Zhou, Man, et al.
Publicado: (2021)

Therapeutic Potential of Prodrugs Towards Targeted Drug Delivery
por: Mishra, Abhinav P., et al.
Publicado: (2018)

Modern Prodrug Design for Targeted Oral Drug Delivery
por: Dahan, Arik, et al.
Publicado: (2014)

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
por: DeVos, Sarah L., et al.
Publicado: (2013)

Modulation of the Expression of the Proinflammatory IL-8 Gene in Cystic Fibrosis Cells by Extracts Deriving from Olive Mill Waste Water
por: Lampronti, Ilaria, et al.
Publicado: (2013)

Drug-Initiated Synthesis of Polymer Prodrugs: Combining Simplicity and Efficacy in Drug Delivery†
por: Nicolas, Julien
Publicado: (2016)

Targeted Drug Delivery to the Central Nervous System Using Extracellular Vesicles
por: Zhou, Lina, et al.
Publicado: (2022)

Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System
por: Crowe, Tyler P., et al.
Publicado: (2022)

Self-assembling prodrug nanotherapeutics for synergistic tumor targeted drug delivery
por: Wang, Zhiren, et al.
Publicado: (2020)

Delivery of Gemcitabine Prodrugs Employing Mesoporous Silica Nanoparticles
por: Malfanti, Alessio, et al.
Publicado: (2016)

Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study
por: Fallacara, Arianna, et al.
Publicado: (2017)

Editorial: Intranasal Delivery of Central Nervous System Active Drugs: Opportunities and Challenges
por: Rodrigues, Márcio, et al.
Publicado: (2022)

Odorants could elicit repair processes in melanized neuronal and skin cells
por: Pavan, Barbara, et al.
Publicado: (2017)

Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system
por: Wang, Qinghua, et al.
Publicado: (2021)

In Vitro and In Vivo Evaluation of Microparticulate Drug Delivery Systems Composed of Macromolecular Prodrugs
por: Onishi, Hiraku, et al.
Publicado: (2008)

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system
por: Lee, Jong Bong, et al.
Publicado: (2018)

Phospholipid prodrug conjugates of insoluble chemotherapeutic agents for ultrasound targeted drug delivery
por: Márquez, Mendi G., et al.
Publicado: (2020)

Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery
por: Huang, Lingling, et al.
Publicado: (2022)

The evolution of nucleosidic analogues: self-assembly of prodrugs into nanoparticles for cancer drug delivery
por: Baroud, Milad, et al.
Publicado: (2021)

A Comparative Evaluation of Hydroxycamptothecin Drug Nanorods With and Without Methotrexate Prodrug Functionalization for Drug Delivery
por: Guo, Fuqiang, et al.
Publicado: (2016)

Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery
por: Pan, Dipanjan, et al.
Publicado: (2016)

From prodrug to pro-prodrug: hypoxia-sensitive antibody–drug conjugates
por: Wang, Yanming, et al.
Publicado: (2022)

Novel Therapeutic Delivery of Nanocurcumin in Central Nervous System Related Disorders
por: Panzarini, Elisa, et al.
Publicado: (2020)

Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system
por: Gonzalez, Ana Maria, et al.
Publicado: (2011)

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
por: Serwer, Laura, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_67hrje1qpmqjc61f5q8amniml7