Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin

Two-, three- and four-arm, star-shaped poly(ε-caprolactone) and poly(D,L‑lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol and poly(ethylene glycol) as initiators an...

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Autores principales: Sobczak, Marcin, Witkowska, Ewa, Olędzka, Ewa, Kolodziejski, Waclaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245082/
https://www.ncbi.nlm.nih.gov/pubmed/18259133
http://dx.doi.org/10.3390/molecules13010096
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author Sobczak, Marcin
Witkowska, Ewa
Olędzka, Ewa
Kolodziejski, Waclaw
author_facet Sobczak, Marcin
Witkowska, Ewa
Olędzka, Ewa
Kolodziejski, Waclaw
author_sort Sobczak, Marcin
collection PubMed
description Two-, three- and four-arm, star-shaped poly(ε-caprolactone) and poly(D,L‑lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. Thus obtained oligomers were successfully used in the synthesis of novel macromolecular prodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated by means of MALDI-TOF MS, NMR and IR studies. 
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spelling pubmed-62450822018-11-26 Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin Sobczak, Marcin Witkowska, Ewa Olędzka, Ewa Kolodziejski, Waclaw Molecules Full Paper Two-, three- and four-arm, star-shaped poly(ε-caprolactone) and poly(D,L‑lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. Thus obtained oligomers were successfully used in the synthesis of novel macromolecular prodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated by means of MALDI-TOF MS, NMR and IR studies.  MDPI 2008-01-18 /pmc/articles/PMC6245082/ /pubmed/18259133 http://dx.doi.org/10.3390/molecules13010096 Text en © 2008 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Full Paper
Sobczak, Marcin
Witkowska, Ewa
Olędzka, Ewa
Kolodziejski, Waclaw
Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin
title Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin
title_full Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin
title_fullStr Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin
title_full_unstemmed Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin
title_short Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin
title_sort synthesis and structural analysis of polyester prodrugs of norfloxacin
topic Full Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245082/
https://www.ncbi.nlm.nih.gov/pubmed/18259133
http://dx.doi.org/10.3390/molecules13010096
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AT kolodziejskiwaclaw synthesisandstructuralanalysisofpolyesterprodrugsofnorfloxacin

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