Fluorinated Analogs of Malachite Green: Synthesis and Toxicity

A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and...

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Detalles Bibliográficos
Autores principales: Kraus, George A., Jeon, Insik, Nilsen-Hamilton, Marit, Awad, Ahmed M., Banerjee, Jayeeta, Parvin, Bahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245195/
https://www.ncbi.nlm.nih.gov/pubmed/18463600
http://dx.doi.org/10.3390/molecules13040986
Descripción
Sumario:A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells.

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