Fluorinated Analogs of Malachite Green: Synthesis and Toxicity

A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and...

Descripción completa

Detalles Bibliográficos
Autores principales: Kraus, George A., Jeon, Insik, Nilsen-Hamilton, Marit, Awad, Ahmed M., Banerjee, Jayeeta, Parvin, Bahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245195/
https://www.ncbi.nlm.nih.gov/pubmed/18463600
http://dx.doi.org/10.3390/molecules13040986
_version_ 1783372192955760640
author Kraus, George A.
Jeon, Insik
Nilsen-Hamilton, Marit
Awad, Ahmed M.
Banerjee, Jayeeta
Parvin, Bahram
author_facet Kraus, George A.
Jeon, Insik
Nilsen-Hamilton, Marit
Awad, Ahmed M.
Banerjee, Jayeeta
Parvin, Bahram
author_sort Kraus, George A.
collection PubMed
description A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells.
format Online
Article
Text
id pubmed-6245195
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62451952018-11-26 Fluorinated Analogs of Malachite Green: Synthesis and Toxicity Kraus, George A. Jeon, Insik Nilsen-Hamilton, Marit Awad, Ahmed M. Banerjee, Jayeeta Parvin, Bahram Molecules Article A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells. MDPI 2008-04-27 /pmc/articles/PMC6245195/ /pubmed/18463600 http://dx.doi.org/10.3390/molecules13040986 Text en © 2008 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Kraus, George A.
Jeon, Insik
Nilsen-Hamilton, Marit
Awad, Ahmed M.
Banerjee, Jayeeta
Parvin, Bahram
Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
title Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
title_full Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
title_fullStr Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
title_full_unstemmed Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
title_short Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
title_sort fluorinated analogs of malachite green: synthesis and toxicity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245195/
https://www.ncbi.nlm.nih.gov/pubmed/18463600
http://dx.doi.org/10.3390/molecules13040986
work_keys_str_mv AT krausgeorgea fluorinatedanalogsofmalachitegreensynthesisandtoxicity
AT jeoninsik fluorinatedanalogsofmalachitegreensynthesisandtoxicity
AT nilsenhamiltonmarit fluorinatedanalogsofmalachitegreensynthesisandtoxicity
AT awadahmedm fluorinatedanalogsofmalachitegreensynthesisandtoxicity
AT banerjeejayeeta fluorinatedanalogsofmalachitegreensynthesisandtoxicity
AT parvinbahram fluorinatedanalogsofmalachitegreensynthesisandtoxicity

Ejemplares similares