A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata

Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2α,3β-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were el...

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Detalles Bibliográficos
Autores principales: Olmedo, Dionisio A., López-Pérez, José L., del Olmo, Esther, Vásquez, Yelkaira, San Feliciano, Arturo, Gupta, Mahabir P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245197/
https://www.ncbi.nlm.nih.gov/pubmed/19037183
http://dx.doi.org/10.3390/molecules13112915
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author Olmedo, Dionisio A.
López-Pérez, José L.
del Olmo, Esther
Vásquez, Yelkaira
San Feliciano, Arturo
Gupta, Mahabir P.
author_facet Olmedo, Dionisio A.
López-Pérez, José L.
del Olmo, Esther
Vásquez, Yelkaira
San Feliciano, Arturo
Gupta, Mahabir P.
author_sort Olmedo, Dionisio A.
collection PubMed
description Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2α,3β-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI(50) values from 1.2 to 3.3 μg/mL.
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spelling pubmed-62451972018-11-30 A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata Olmedo, Dionisio A. López-Pérez, José L. del Olmo, Esther Vásquez, Yelkaira San Feliciano, Arturo Gupta, Mahabir P. Molecules Communication Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2α,3β-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI(50) values from 1.2 to 3.3 μg/mL. MDPI 2008-11-25 /pmc/articles/PMC6245197/ /pubmed/19037183 http://dx.doi.org/10.3390/molecules13112915 Text en © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Olmedo, Dionisio A.
López-Pérez, José L.
del Olmo, Esther
Vásquez, Yelkaira
San Feliciano, Arturo
Gupta, Mahabir P.
A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata
title A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata
title_full A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata
title_fullStr A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata
title_full_unstemmed A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata
title_short A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata
title_sort new cytotoxic friedelane acid – pluricostatic acid – and other compounds from the leaves of marila pluricostata
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245197/
https://www.ncbi.nlm.nih.gov/pubmed/19037183
http://dx.doi.org/10.3390/molecules13112915
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