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FOXO1 Deletion Reverses the Effect of Diabetic-Induced Impaired Fracture Healing

Type 1 diabetes impairs fracture healing. We tested the hypothesis that diabetes affects chondrocytes to impair fracture healing through a mechanism that involves the transcription factor FOXO1. Type 1 diabetes was induced by streptozotocin in mice with FOXO1 deletion in chondrocytes (Col2α1Cre(+).F...

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Detalles Bibliográficos
Autores principales:	Alharbi, Mohammed A., Zhang, Citong, Lu, Chanyi, Milovanova, Tatyana N., Yi, Leah, Ryu, Je Dong, Jiao, Hongli, Dong, Guangyu, O’Connor, J. Patrick, Graves, Dana T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2018
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245226/ https://www.ncbi.nlm.nih.gov/pubmed/30279162 http://dx.doi.org/10.2337/db18-0340

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