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Synthesis, Biological Evaluation, and Modeling of Dimeric PPI Analogues as Novel DNA Minor Groove Binders

A series of symmetrical dimeric proton pump inhibitor (PPI) analogues, designed as novel type DNA minor groove binders, was synthesized and evaluated for anti-tumor activity. Some of these new compounds showed IC(50) values below 10 μM in an in vitro anti-tumor test. A molecular modeling study was p...

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Detalles Bibliográficos
Autores principales:	Yang, Yan-Hui, Wang, Qing-He, Nie, Han, Chen, Hong, Cheng, Mao-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245273/ https://www.ncbi.nlm.nih.gov/pubmed/18560336 http://dx.doi.org/10.3390/molecules13051179

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