Cargando…

CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo

BACKGROUND: Glioblastoma multiforme (GBM) remains to be one of the top lethal cancer types for adult to date. Current GBM therapies suffer greatly from the highly heterogeneous and adaptable nature of GBM cells, indicating an urgent need of alternative therapeutic options. In this study, we focused...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Wei, Wang, Jiajia, Wang, Baocheng, Liu, Fang, Li, Meng, Zhao, Yang, Zhang, Chenran, Li, Qifeng, Chen, Juxiang, Zhang, Liye, Tang, Yujie, Ma, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245350/ https://www.ncbi.nlm.nih.gov/pubmed/30532595 http://dx.doi.org/10.2147/CMAR.S183696

Ejemplares similares

Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma
por: Meng, Wei, et al.
Publicado: (2018)

Enhanced efficacy of histone deacetylase inhibitor panobinostat combined with dual PI3K/mTOR inhibitor BEZ235 against glioblastoma
por: Meng, Wei, et al.
Publicado: (2019)

Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM
por: Liu, Bao, et al.
Publicado: (2022)

Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells
por: Liu, Feili, et al.
Publicado: (2016)

Advances in nanotechnology for the treatment of GBM
por: Wei, Dongyan, et al.
Publicado: (2023)

Combined inhibition of CDK and HDAC as a promising therapeutic strategy for both cutaneous and uveal metastatic melanoma
por: Heijkants, Renier, et al.
Publicado: (2017)

Therapeutic strategies of glioblastoma (GBM): The current advances in the molecular targets and bioactive small molecule compounds
por: Liu, Hui, et al.
Publicado: (2022)

Re-thinking the preclinical development of GBM therapeutics
por: Cosset, Érika, et al.
Publicado: (2018)

Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma
por: Chen, Hua-Dong, et al.
Publicado: (2020)

Delivering Glioblastoma a Kick—DGKα Inhibition as a Promising Therapeutic Strategy for GBM
por: Purow, Benjamin
Publicado: (2022)

Heterogeneous EGFR, CDK4, MDM4, and PDGFRA Gene Expression Profiles in Primary GBM: No Association with Patient Survival
por: González-Tablas, María, et al.
Publicado: (2020)

Novel therapeutic strategy for melanoma based on albendazole and the CDK4/6 inhibitor palbociclib
por: Zhu, Lin, et al.
Publicado: (2022)

Computer Implementation of a New Therapeutic Model for GBM Tumor
por: Jamali Nazari, Ali, et al.
Publicado: (2014)

Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic Potential
por: Stackhouse, Christian T., et al.
Publicado: (2020)

Migration-Associated Transportome and Therapeutic Potential in Glioblastoma Multiforme (GBM)
por: Vaid, Samir, et al.
Publicado: (2023)

Hijacking Sexual Immuno-Privilege in GBM—An Immuno-Evasion Strategy
por: Sharpe, Martyn A., et al.
Publicado: (2021)

Research on fault diagnosis system for belt conveyor based on internet of things and the LightGBM model
por: Wang, Meng, et al.
Publicado: (2023)

Combining an Autophagy Inhibitor, MPT0L145, with Abemaciclib Is a New Therapeutic Strategy in GBM Treatment
por: Hsieh, Tsung-Han, et al.
Publicado: (2021)

Expressions and significances of CTSL, the target of COVID‐19 on GBM
por: Dong, Qiang, et al.
Publicado: (2021)

Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM
por: Juric, Viktorija, et al.
Publicado: (2021)

TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways
por: Singh, Karnika, et al.
Publicado: (2023)

Anti-GBM-Nephritis
por: Windpessl, Martin, et al.
Publicado: (2023)

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis
por: Hellvard, Annelie, et al.
Publicado: (2016)

Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma
por: Li, Meng, et al.
Publicado: (2022)

A Review of Potential Therapeutic Strategies for COVID-19
por: Meng, Jiajia, et al.
Publicado: (2022)

Handcrafted and Deep Learning-Based Radiomic Models Can Distinguish GBM from Brain Metastasis
por: Liu, Zhiyuan, et al.
Publicado: (2021)

CDK6 Immunophenotype Implicates Potential Therapeutic Application of CDK4/6 Inhibitors in Urothelial Carcinoma
por: Sun, Ran, et al.
Publicado: (2022)

GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway
por: Mahata, Barun, et al.
Publicado: (2015)

A Preclinical Investigation of GBM-N019 as a Potential Inhibitor of Glioblastoma via Exosomal mTOR/CDK6/STAT3 Signaling
por: Wu, Alexander T. H., et al.
Publicado: (2021)

Fully automatic GBM segmentation in the TCGA-GBM dataset: Prognosis and correlation with VASARI features
por: Rios Velazquez, Emmanuel, et al.
Publicado: (2015)

Differentiation of Human GBM From Non-GBM Brain Tissue With Polarization Imaging Technique
por: Liu, Yi-Rong, et al.
Publicado: (2022)

Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression
por: Chen, Zhigang, et al.
Publicado: (2023)

Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells
por: Mukherjee, Sumit, et al.
Publicado: (2018)

The CDK-activating kinase Cdk7: Taking yes for an answer
por: Schachter, Miriam Merzel, et al.
Publicado: (2013)

Cyclin-dependent kinase 7 (CDK7) is an emerging prognostic biomarker and therapeutic target in osteosarcoma
por: Ma, Hangzhan, et al.
Publicado: (2021)

The overexpression of GPX8 is correlated with poor prognosis in GBM patients
por: Li, Sibo, et al.
Publicado: (2022)

Anti-GBM disease with a mild relapsing course and low levels of anti-GBM autoantibodies
por: Segelmark, Mårten, et al.
Publicado: (2012)

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
por: Dannappel, Marius Volker, et al.
Publicado: (2019)

Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model
por: Jacobs, Valerie L, et al.
Publicado: (2011)

Coactosin-Like Protein (COTL1) Promotes Glioblastoma (GBM) Growth in vitro and in vivo
por: Shao, Shike, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_94vgls67c5qsm5ugmqhvo0upba