Antifouling Metabolites from the Mangrove Plant Ceriops tagal

The new diterpene methoxy-ent-8(14)-pimarenely-15-one (1) and three known metabolites: ent-8(14)-pimarene-15R,16-diol (2), stigmasterol (3) and β-sitosterol (4), were isolated from the roots of the mangrove plant Ceriops tagal. Their structures and relative stereochemistry were elucidated by means o...

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Detalles Bibliográficos
Autores principales: Chen, Jun De, Feng, Dan Qin, Yang, Zhi Wei, Wang, Zhan Chang, Qiu, Yan, Lin, Yi Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245354/
https://www.ncbi.nlm.nih.gov/pubmed/18305413
http://dx.doi.org/10.3390/molecules13020212
Descripción
Sumario:The new diterpene methoxy-ent-8(14)-pimarenely-15-one (1) and three known metabolites: ent-8(14)-pimarene-15R,16-diol (2), stigmasterol (3) and β-sitosterol (4), were isolated from the roots of the mangrove plant Ceriops tagal. Their structures and relative stereochemistry were elucidated by means of extensive NMR, IR and MS analysis. Compounds 1, 2, 3 and 4 exhibited significant antifouling activities against cyprid larvae of the barnacle Balanus albicostatus Pilsbry, with EC(50) values of 0.32 ± 0.01, 0.04 ± 0.00, 4.05 ± 0.15 and 18.47 ± 0.40 µg/cm(2), respectively, whereas their toxicities towards cyprids were very low, with LC(50) values all above 10 µg/cm(2).

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