A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria

Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxy-polyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and s...

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Detalles Bibliográficos
Autores principales: Qiu, Yan, Wang, Xiu Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245356/
https://www.ncbi.nlm.nih.gov/pubmed/18596654
http://dx.doi.org/10.3390/molecules13061275
Descripción
Sumario:Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxy-polyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti-HIV activity on HIV-1 RT was evaluated. Compounds 3-6 displayed moderate inhibitory activity, with IC(50) values of 239.7, 16.4, 176.1, and 130.4 µM, respectively, while 1 and 2 were found to be inactive against the same biological target.

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