A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria

Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxy-polyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and s...

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Detalles Bibliográficos
Autores principales: Qiu, Yan, Wang, Xiu Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245356/
https://www.ncbi.nlm.nih.gov/pubmed/18596654
http://dx.doi.org/10.3390/molecules13061275
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author Qiu, Yan
Wang, Xiu Min
author_facet Qiu, Yan
Wang, Xiu Min
author_sort Qiu, Yan
collection PubMed
description Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxy-polyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti-HIV activity on HIV-1 RT was evaluated. Compounds 3-6 displayed moderate inhibitory activity, with IC(50) values of 239.7, 16.4, 176.1, and 130.4 µM, respectively, while 1 and 2 were found to be inactive against the same biological target.
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spelling pubmed-62453562018-11-26 A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria Qiu, Yan Wang, Xiu Min Molecules Communication Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxy-polyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti-HIV activity on HIV-1 RT was evaluated. Compounds 3-6 displayed moderate inhibitory activity, with IC(50) values of 239.7, 16.4, 176.1, and 130.4 µM, respectively, while 1 and 2 were found to be inactive against the same biological target. MDPI 2008-06-06 /pmc/articles/PMC6245356/ /pubmed/18596654 http://dx.doi.org/10.3390/molecules13061275 Text en © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Qiu, Yan
Wang, Xiu Min
A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria
title A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria
title_full A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria
title_fullStr A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria
title_full_unstemmed A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria
title_short A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria
title_sort new sesquiterpenoid hydroquinone from the marine sponge dysidea arenaria
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245356/
https://www.ncbi.nlm.nih.gov/pubmed/18596654
http://dx.doi.org/10.3390/molecules13061275
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