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Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an α,β-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can be classified into fiv...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245361/ https://www.ncbi.nlm.nih.gov/pubmed/18305428 http://dx.doi.org/10.3390/molecules13020412 |