A Structure-Activity Study of Antibacterial Diterpenoids

An analysis of the antibacterial activities of 15 terpenoids, eleven of which were previously described by us and four were extracted from the literature, suggested two structural requirements for activity of these and related compounds: a hydrophobic moiety, consisting of a substituted decalin skel...

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Detalles Bibliográficos
Autores principales: Urzúa, Alejandro, Rezende,  Marcos C., Mascayano, Carolina, Vásquez, Loretta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245368/
https://www.ncbi.nlm.nih.gov/pubmed/18463590
http://dx.doi.org/10.3390/molecules13040822
Descripción
Sumario:An analysis of the antibacterial activities of 15 terpenoids, eleven of which were previously described by us and four were extracted from the literature, suggested two structural requirements for activity of these and related compounds: a hydrophobic moiety, consisting of a substituted decalin skeleton, and a hydrophilic region possessing one hydrogen-bond-donor group. These structural requirements are responsible for an optimal insertion of these and related compounds into cell membranes, as suggested by the results of docking some of these compounds into a model phospholipid bilayer.

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