Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens

The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobial metabolites from the sponge Ulosa sp., were isolated and identified...

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Detalles Bibliográficos
Autores principales: Ogi, Takayuki, Taira, Junsei, Margiastuti, Palupi, Ueda, Katsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245384/
https://www.ncbi.nlm.nih.gov/pubmed/18463568
http://dx.doi.org/10.3390/molecules13030595
Descripción
Sumario:The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobial metabolites from the sponge Ulosa sp., were isolated and identified as major components of the ascidian Diplosoma virens. In this paper, full spectral data for 2 and complete (13)C-NMR data for 1, based on 2D NMR measurements, are provided for the first time. Compounds 1 and 2 showed cytotoxity against HCT116 cells (human colorectal cancer cells) by triggering apoptotic cell death.

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