Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens

The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobial metabolites from the sponge Ulosa sp., were isolated and identified...

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Autores principales: Ogi, Takayuki, Taira, Junsei, Margiastuti, Palupi, Ueda, Katsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245384/
https://www.ncbi.nlm.nih.gov/pubmed/18463568
http://dx.doi.org/10.3390/molecules13030595
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author Ogi, Takayuki
Taira, Junsei
Margiastuti, Palupi
Ueda, Katsuhiro
author_facet Ogi, Takayuki
Taira, Junsei
Margiastuti, Palupi
Ueda, Katsuhiro
author_sort Ogi, Takayuki
collection PubMed
description The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobial metabolites from the sponge Ulosa sp., were isolated and identified as major components of the ascidian Diplosoma virens. In this paper, full spectral data for 2 and complete (13)C-NMR data for 1, based on 2D NMR measurements, are provided for the first time. Compounds 1 and 2 showed cytotoxity against HCT116 cells (human colorectal cancer cells) by triggering apoptotic cell death.
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spelling pubmed-62453842018-11-26 Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens Ogi, Takayuki Taira, Junsei Margiastuti, Palupi Ueda, Katsuhiro Molecules Communication The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7a-dihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobial metabolites from the sponge Ulosa sp., were isolated and identified as major components of the ascidian Diplosoma virens. In this paper, full spectral data for 2 and complete (13)C-NMR data for 1, based on 2D NMR measurements, are provided for the first time. Compounds 1 and 2 showed cytotoxity against HCT116 cells (human colorectal cancer cells) by triggering apoptotic cell death. MDPI 2008-03-11 /pmc/articles/PMC6245384/ /pubmed/18463568 http://dx.doi.org/10.3390/molecules13030595 Text en © 2008 MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Communication
Ogi, Takayuki
Taira, Junsei
Margiastuti, Palupi
Ueda, Katsuhiro
Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
title Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
title_full Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
title_fullStr Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
title_full_unstemmed Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
title_short Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
title_sort cytotoxic metabolites from the okinawan ascidian diplosoma virens
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245384/
https://www.ncbi.nlm.nih.gov/pubmed/18463568
http://dx.doi.org/10.3390/molecules13030595
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AT tairajunsei cytotoxicmetabolitesfromtheokinawanascidiandiplosomavirens
AT margiastutipalupi cytotoxicmetabolitesfromtheokinawanascidiandiplosomavirens
AT uedakatsuhiro cytotoxicmetabolitesfromtheokinawanascidiandiplosomavirens

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