New Di-(β-chloroethyl)-α-amides on N-(meta-Acylamino-benzoyl)-D,L-aminoacid Supports with Antitumoral Activity

In order to obtain new compounds with antitumoural action the N-(meta-acylaminobenzoyl)-α-acylaminobenzoyl)-α-aminoacids 4-9 were prepared. These compounds were subsequently converted into the corresponding Δ(2)-oxazolin-5-ones 10-15, which in turn were submitted to a ring opening reaction with di-(...

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Autores principales: Sunel, Valeriu, Popa, Marcel, Desbrières, Jacques, Profire, Lenuta, Otilia, Pintilie, Catalina, Lionte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245399/
https://www.ncbi.nlm.nih.gov/pubmed/18259140
http://dx.doi.org/10.3390/molecules13010177
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author Sunel, Valeriu
Popa, Marcel
Desbrières, Jacques
Profire, Lenuta
Otilia, Pintilie
Catalina, Lionte
author_facet Sunel, Valeriu
Popa, Marcel
Desbrières, Jacques
Profire, Lenuta
Otilia, Pintilie
Catalina, Lionte
author_sort Sunel, Valeriu
collection PubMed
description In order to obtain new compounds with antitumoural action the N-(meta-acylaminobenzoyl)-α-acylaminobenzoyl)-α-aminoacids 4-9 were prepared. These compounds were subsequently converted into the corresponding Δ(2)-oxazolin-5-ones 10-15, which in turn were submitted to a ring opening reaction with di-(β-chloroethyl)amine to afford the peptide supported N-mustards 16-21, which showed low toxicity and cytostatic activity similar to that of sarcolisine against the Ehrlich ascite and Walker 253 carcinosarcoma.
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spelling pubmed-62453992018-11-26 New Di-(β-chloroethyl)-α-amides on N-(meta-Acylamino-benzoyl)-D,L-aminoacid Supports with Antitumoral Activity Sunel, Valeriu Popa, Marcel Desbrières, Jacques Profire, Lenuta Otilia, Pintilie Catalina, Lionte Molecules Full Research Paper In order to obtain new compounds with antitumoural action the N-(meta-acylaminobenzoyl)-α-acylaminobenzoyl)-α-aminoacids 4-9 were prepared. These compounds were subsequently converted into the corresponding Δ(2)-oxazolin-5-ones 10-15, which in turn were submitted to a ring opening reaction with di-(β-chloroethyl)amine to afford the peptide supported N-mustards 16-21, which showed low toxicity and cytostatic activity similar to that of sarcolisine against the Ehrlich ascite and Walker 253 carcinosarcoma. MDPI 2008-01-28 /pmc/articles/PMC6245399/ /pubmed/18259140 http://dx.doi.org/10.3390/molecules13010177 Text en © 2008 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Full Research Paper
Sunel, Valeriu
Popa, Marcel
Desbrières, Jacques
Profire, Lenuta
Otilia, Pintilie
Catalina, Lionte
New Di-(β-chloroethyl)-α-amides on N-(meta-Acylamino-benzoyl)-D,L-aminoacid Supports with Antitumoral Activity
title New Di-(β-chloroethyl)-α-amides on N-(meta-Acylamino-benzoyl)-D,L-aminoacid Supports with Antitumoral Activity
title_full New Di-(β-chloroethyl)-α-amides on N-(meta-Acylamino-benzoyl)-D,L-aminoacid Supports with Antitumoral Activity
title_fullStr New Di-(β-chloroethyl)-α-amides on N-(meta-Acylamino-benzoyl)-D,L-aminoacid Supports with Antitumoral Activity
title_full_unstemmed New Di-(β-chloroethyl)-α-amides on N-(meta-Acylamino-benzoyl)-D,L-aminoacid Supports with Antitumoral Activity
title_short New Di-(β-chloroethyl)-α-amides on N-(meta-Acylamino-benzoyl)-D,L-aminoacid Supports with Antitumoral Activity
title_sort new di-(β-chloroethyl)-α-amides on n-(meta-acylamino-benzoyl)-d,l-aminoacid supports with antitumoral activity
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245399/
https://www.ncbi.nlm.nih.gov/pubmed/18259140
http://dx.doi.org/10.3390/molecules13010177
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