Prodrugs for Amines

The purpose of this work is to review the published strategies for the production of prodrugs of amines. The review is divided in two main groups of approaches: those that rely on enzymatic activation and those that take advantage of physiological chemical conditions for release of the drugs. A comp...

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Detalles Bibliográficos
Autores principales: Simplício, Ana L., Clancy, John M., Gilmer, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245426/
https://www.ncbi.nlm.nih.gov/pubmed/18463563
http://dx.doi.org/10.3390/molecules13030519
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author Simplício, Ana L.
Clancy, John M.
Gilmer, John F.
author_facet Simplício, Ana L.
Clancy, John M.
Gilmer, John F.
author_sort Simplício, Ana L.
collection PubMed
description The purpose of this work is to review the published strategies for the production of prodrugs of amines. The review is divided in two main groups of approaches: those that rely on enzymatic activation and those that take advantage of physiological chemical conditions for release of the drugs. A compilation of the most important approaches is presented in the form of a table, where the main advantages and disadvantages of each strategy are also referred.
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spelling pubmed-62454262018-11-26 Prodrugs for Amines Simplício, Ana L. Clancy, John M. Gilmer, John F. Molecules Review The purpose of this work is to review the published strategies for the production of prodrugs of amines. The review is divided in two main groups of approaches: those that rely on enzymatic activation and those that take advantage of physiological chemical conditions for release of the drugs. A compilation of the most important approaches is presented in the form of a table, where the main advantages and disadvantages of each strategy are also referred. MDPI 2008-03-03 /pmc/articles/PMC6245426/ /pubmed/18463563 http://dx.doi.org/10.3390/molecules13030519 Text en © 2008 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Review
Simplício, Ana L.
Clancy, John M.
Gilmer, John F.
Prodrugs for Amines
title Prodrugs for Amines
title_full Prodrugs for Amines
title_fullStr Prodrugs for Amines
title_full_unstemmed Prodrugs for Amines
title_short Prodrugs for Amines
title_sort prodrugs for amines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245426/
https://www.ncbi.nlm.nih.gov/pubmed/18463563
http://dx.doi.org/10.3390/molecules13030519
work_keys_str_mv AT simplicioanal prodrugsforamines
AT clancyjohnm prodrugsforamines
AT gilmerjohnf prodrugsforamines

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