Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives

A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, (1)H-NMR, MS). A preliminary evaluation of the anticonvulsant properties of the prep...

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Detalles Bibliográficos
Autores principales: Georgey, Hanan, Abdel-Gawad, Nagwa, Abbas, Safinaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245438/
https://www.ncbi.nlm.nih.gov/pubmed/18927518
http://dx.doi.org/10.3390/molecules13102557
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author Georgey, Hanan
Abdel-Gawad, Nagwa
Abbas, Safinaz
author_facet Georgey, Hanan
Abdel-Gawad, Nagwa
Abbas, Safinaz
author_sort Georgey, Hanan
collection PubMed
description A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, (1)H-NMR, MS). A preliminary evaluation of the anticonvulsant properties of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to a diazepam standard.
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spelling pubmed-62454382018-11-30 Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives Georgey, Hanan Abdel-Gawad, Nagwa Abbas, Safinaz Molecules Article A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, (1)H-NMR, MS). A preliminary evaluation of the anticonvulsant properties of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to a diazepam standard. MDPI 2008-10-16 /pmc/articles/PMC6245438/ /pubmed/18927518 http://dx.doi.org/10.3390/molecules13102557 Text en © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Georgey, Hanan
Abdel-Gawad, Nagwa
Abbas, Safinaz
Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
title Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
title_full Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
title_fullStr Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
title_full_unstemmed Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
title_short Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
title_sort synthesis and anticonvulsant activity of some quinazolin-4-(3h)-one derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245438/
https://www.ncbi.nlm.nih.gov/pubmed/18927518
http://dx.doi.org/10.3390/molecules13102557
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