Effect of Dehydroaltenusin-C12 Derivative, a Selective DNA Polymerase α Inhibitor, on DNA Replication in Cultured Cells

Dehydroaltenusin is a selective inhibitor of mammalian DNA polymerase α (pol α) from a fungus (Alternaria tennuis). We have designed, synthesized, and characterized a derivative of dehydroaltenusin conjugated with a C12-alkyl side chain (dehydroaltenusin-C12 [C12]). C12 was the strongest pol α inhib...

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Detalles Bibliográficos
Autores principales: Kuriyama, Isoko, Mizuno, Takeshi, Fukudome, Keishi, Kuramochi, Kouji, Tsubaki, Kazunori, Usui, Takeo, Imamoto, Naoko, Sakaguchi, Kengo, Sugawara, Fumio, Yoshida, Hiromi, Mizushina, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245447/
https://www.ncbi.nlm.nih.gov/pubmed/19043348
http://dx.doi.org/10.3390/molecules13122948

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