Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D(1) Receptor

Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydro-corybulbine. The tertiary alkaloids were further analyzed by...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Zhong-Ze, Xu, Wei, Jensen, Niels H., Roth, Bryan L., Liu-Chen, Lee-Yuan, Lee, David Y. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245449/
https://www.ncbi.nlm.nih.gov/pubmed/18830156
http://dx.doi.org/10.3390/molecules13092303
_version_ 1783372242937184256
author Ma, Zhong-Ze
Xu, Wei
Jensen, Niels H.
Roth, Bryan L.
Liu-Chen, Lee-Yuan
Lee, David Y. W.
author_facet Ma, Zhong-Ze
Xu, Wei
Jensen, Niels H.
Roth, Bryan L.
Liu-Chen, Lee-Yuan
Lee, David Y. W.
author_sort Ma, Zhong-Ze
collection PubMed
description Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydro-corybulbine. The tertiary alkaloids were further analyzed by chiral HPLC to determine the ratios of d-and l-isomers. The isolated compounds were screened for their binding affinities at the dopamine D(1) receptor. Isocorypalmine had the highest affinity (K(i) = 83 nM). The structure-affinity relationships of these alkaloids are discussed.
format Online
Article
Text
id pubmed-6245449
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62454492018-11-30 Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D(1) Receptor Ma, Zhong-Ze Xu, Wei Jensen, Niels H. Roth, Bryan L. Liu-Chen, Lee-Yuan Lee, David Y. W. Molecules Communication Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydro-corybulbine. The tertiary alkaloids were further analyzed by chiral HPLC to determine the ratios of d-and l-isomers. The isolated compounds were screened for their binding affinities at the dopamine D(1) receptor. Isocorypalmine had the highest affinity (K(i) = 83 nM). The structure-affinity relationships of these alkaloids are discussed. MDPI 2008-09-25 /pmc/articles/PMC6245449/ /pubmed/18830156 http://dx.doi.org/10.3390/molecules13092303 Text en © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Ma, Zhong-Ze
Xu, Wei
Jensen, Niels H.
Roth, Bryan L.
Liu-Chen, Lee-Yuan
Lee, David Y. W.
Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D(1) Receptor
title Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D(1) Receptor
title_full Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D(1) Receptor
title_fullStr Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D(1) Receptor
title_full_unstemmed Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D(1) Receptor
title_short Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D(1) Receptor
title_sort isoquinoline alkaloids isolated from corydalis yanhusuo and their binding affinities at the dopamine d(1) receptor
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245449/
https://www.ncbi.nlm.nih.gov/pubmed/18830156
http://dx.doi.org/10.3390/molecules13092303
work_keys_str_mv AT mazhongze isoquinolinealkaloidsisolatedfromcorydalisyanhusuoandtheirbindingaffinitiesatthedopamined1receptor
AT xuwei isoquinolinealkaloidsisolatedfromcorydalisyanhusuoandtheirbindingaffinitiesatthedopamined1receptor
AT jensennielsh isoquinolinealkaloidsisolatedfromcorydalisyanhusuoandtheirbindingaffinitiesatthedopamined1receptor
AT rothbryanl isoquinolinealkaloidsisolatedfromcorydalisyanhusuoandtheirbindingaffinitiesatthedopamined1receptor
AT liuchenleeyuan isoquinolinealkaloidsisolatedfromcorydalisyanhusuoandtheirbindingaffinitiesatthedopamined1receptor
AT leedavidyw isoquinolinealkaloidsisolatedfromcorydalisyanhusuoandtheirbindingaffinitiesatthedopamined1receptor

Ejemplares similares