A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of4(3H)-Quinazolinones

We have investigated a microwave–assisted synthesis of 4(3H)–quinazolinones by condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines, using Keggin-type heteropolyacids (H(3)PW(12)O(40)∙13H(2)O, H(4)SiW(12)O(40)∙13H(2)O, H(4)SiMo(12)O(40)∙13H(2)O or H(3)PMo(12)O(40)∙...

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Autores principales: Ighilahriz, Karima, Boutemeur, Baya, Chami, Fariza, Rabia, Cherifa, Hamdi, Maâmar, Hamdi,  Safouane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245457/
https://www.ncbi.nlm.nih.gov/pubmed/18463579
http://dx.doi.org/10.3390/molecules13040779
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author Ighilahriz, Karima
Boutemeur, Baya
Chami, Fariza
Rabia, Cherifa
Hamdi, Maâmar
Hamdi,  Safouane M.
author_facet Ighilahriz, Karima
Boutemeur, Baya
Chami, Fariza
Rabia, Cherifa
Hamdi, Maâmar
Hamdi,  Safouane M.
author_sort Ighilahriz, Karima
collection PubMed
description We have investigated a microwave–assisted synthesis of 4(3H)–quinazolinones by condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines, using Keggin-type heteropolyacids (H(3)PW(12)O(40)∙13H(2)O, H(4)SiW(12)O(40)∙13H(2)O, H(4)SiMo(12)O(40)∙13H(2)O or H(3)PMo(12)O(40)∙13H(2)O) as catalysts. We found that the the use of H(3)PW(12)O(40)∙13H(2)O acid coupled to microwave irradiation allows a solvent-free, rapid (~13 min) and high-yielding reaction.
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spelling pubmed-62454572018-11-26 A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of4(3H)-Quinazolinones Ighilahriz, Karima Boutemeur, Baya Chami, Fariza Rabia, Cherifa Hamdi, Maâmar Hamdi,  Safouane M. Molecules Article We have investigated a microwave–assisted synthesis of 4(3H)–quinazolinones by condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines, using Keggin-type heteropolyacids (H(3)PW(12)O(40)∙13H(2)O, H(4)SiW(12)O(40)∙13H(2)O, H(4)SiMo(12)O(40)∙13H(2)O or H(3)PMo(12)O(40)∙13H(2)O) as catalysts. We found that the the use of H(3)PW(12)O(40)∙13H(2)O acid coupled to microwave irradiation allows a solvent-free, rapid (~13 min) and high-yielding reaction. MDPI 2008-04-03 /pmc/articles/PMC6245457/ /pubmed/18463579 http://dx.doi.org/10.3390/molecules13040779 Text en © 2008 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Ighilahriz, Karima
Boutemeur, Baya
Chami, Fariza
Rabia, Cherifa
Hamdi, Maâmar
Hamdi,  Safouane M.
A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of4(3H)-Quinazolinones
title A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of4(3H)-Quinazolinones
title_full A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of4(3H)-Quinazolinones
title_fullStr A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of4(3H)-Quinazolinones
title_full_unstemmed A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of4(3H)-Quinazolinones
title_short A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of4(3H)-Quinazolinones
title_sort microwave-assisted and heteropolyacids-catalysed cyclocondensation reaction for the synthesis of4(3h)-quinazolinones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245457/
https://www.ncbi.nlm.nih.gov/pubmed/18463579
http://dx.doi.org/10.3390/molecules13040779
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