Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks

We have uncovered a role for Jumonji inhibitors in overcoming radioresistance through KDM5B inhibition. Pharmacological blockade of Jumonji demethy-lases with JIB-04 leads to specific accumulation of H3K4me3 at sites marked by γH2AX and impaired recruitment of DNA repair factors, preventing resoluti...

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Detalles Bibliográficos
Autores principales: Bayo, Juan, Tran, Tram Anh, Wang, Lei, Peña-Llopis, Samuel, Das, Amit K., Martinez, Elisabeth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245670/
https://www.ncbi.nlm.nih.gov/pubmed/30355483
http://dx.doi.org/10.1016/j.celrep.2018.09.081

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