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Association of CYP2D6 polymorphisms and extrapyramidal symptoms in schizophrenia patients receiving risperidone: a retrospective study

BACKGROUND: Risperidone is mainly metabolized by cytochrome P450 (CYP) 2D6 in the liver. The gene encoding CYP2D6 is highly polymorphic. The average steady-state plasma concentration of risperidone active moiety is higher in the CYP2D6 intermediate metabolizers (IMs) compared with that in the extens...

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Detalles Bibliográficos
Autores principales:	Ito, Takahiro, Yamamoto, Kazuhiro, Ohsawa, Fuminori, Otsuka, Ikuo, Hishimoto, Akitoyo, Sora, Ichiro, Hirai, Midori, Yano, Ikuko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245770/ https://www.ncbi.nlm.nih.gov/pubmed/30479825 http://dx.doi.org/10.1186/s40780-018-0126-y

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