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Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples

BACKGROUND: Because driver mutations provide selective advantage to the mutant clone, they tend to occur at a higher frequency in tumor samples compared to selectively neutral (passenger) mutations. However, mutation frequency alone is insufficient to identify cancer genes because mutability is infl...

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Detalles Bibliográficos
Autores principales:	Gorlov, Ivan P., Pikielny, Claudio W., Frost, Hildreth R., Her, Stephanie C., Cole, Michael D., Strohbehn, Samuel D., Wallace-Bradley, David, Kimmel, Marek, Gorlova, Olga Y., Amos, Christopher I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245819/ https://www.ncbi.nlm.nih.gov/pubmed/30453881 http://dx.doi.org/10.1186/s12859-018-2455-0

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