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Thyroid stimulating hormone suppression time on cardiac function of patients with differentiated thyroid carcinoma

BACKGROUND: This study was to investigate the influence of thyroid stimulating hormone (TSH) suppression time on the cardiac function of differentiated thyroid carcinoma (DTC) patients. METHODS: 105 DTC patients were divided into strict TSH suppression group (model group, TSH ≤ 0.1 mU/L) and general...

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Autores principales: Wang, Ruihua, Yang, Liu, Jin, Shui, Han, Xingmin, Liu, Baoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245826/
https://www.ncbi.nlm.nih.gov/pubmed/30479568
http://dx.doi.org/10.1186/s12935-018-0686-9
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author Wang, Ruihua
Yang, Liu
Jin, Shui
Han, Xingmin
Liu, Baoping
author_facet Wang, Ruihua
Yang, Liu
Jin, Shui
Han, Xingmin
Liu, Baoping
author_sort Wang, Ruihua
collection PubMed
description BACKGROUND: This study was to investigate the influence of thyroid stimulating hormone (TSH) suppression time on the cardiac function of differentiated thyroid carcinoma (DTC) patients. METHODS: 105 DTC patients were divided into strict TSH suppression group (model group, TSH ≤ 0.1 mU/L) and general TSH suppression group (control group, TSH > 0.1 mU/L). According to the suppression time, these two groups were respectively divided into three groups: group within half a year, group between half a year and a year and group more than a year. Gated myocardial perfusion imaging was applied to observe differences of left ventricle (LV) myocardial perfusion, LV diastolic and systolic function and LV systolic synchrony in every group. RESULTS: The left ventricular diastolic function, systolic synchrony and myocardial perfusion level of model group decreased with prolonged suppression time. The values of left ventricular EF, PFR and BPM in patients less than half a year were higher than those in 6 months to 1 year for control group. CONCLUSION: Thyroid stimulating hormone suppression can influence the cardiac function of patients and with the prolongation of suppression time, regardless of the level of TSH suppression, the possibility of cardiac function depression in patients will increase. TSH may lower the risk of cardiovascular disease in high-risk patients than those in TSH patients with moderate or low risk. The drugs improving cardiac function should be used cooperatively in different suppression period to decrease the occurrence rate of cardiac adverse reactions.
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spelling pubmed-62458262018-11-26 Thyroid stimulating hormone suppression time on cardiac function of patients with differentiated thyroid carcinoma Wang, Ruihua Yang, Liu Jin, Shui Han, Xingmin Liu, Baoping Cancer Cell Int Primary Research BACKGROUND: This study was to investigate the influence of thyroid stimulating hormone (TSH) suppression time on the cardiac function of differentiated thyroid carcinoma (DTC) patients. METHODS: 105 DTC patients were divided into strict TSH suppression group (model group, TSH ≤ 0.1 mU/L) and general TSH suppression group (control group, TSH > 0.1 mU/L). According to the suppression time, these two groups were respectively divided into three groups: group within half a year, group between half a year and a year and group more than a year. Gated myocardial perfusion imaging was applied to observe differences of left ventricle (LV) myocardial perfusion, LV diastolic and systolic function and LV systolic synchrony in every group. RESULTS: The left ventricular diastolic function, systolic synchrony and myocardial perfusion level of model group decreased with prolonged suppression time. The values of left ventricular EF, PFR and BPM in patients less than half a year were higher than those in 6 months to 1 year for control group. CONCLUSION: Thyroid stimulating hormone suppression can influence the cardiac function of patients and with the prolongation of suppression time, regardless of the level of TSH suppression, the possibility of cardiac function depression in patients will increase. TSH may lower the risk of cardiovascular disease in high-risk patients than those in TSH patients with moderate or low risk. The drugs improving cardiac function should be used cooperatively in different suppression period to decrease the occurrence rate of cardiac adverse reactions. BioMed Central 2018-11-19 /pmc/articles/PMC6245826/ /pubmed/30479568 http://dx.doi.org/10.1186/s12935-018-0686-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Primary Research
Wang, Ruihua
Yang, Liu
Jin, Shui
Han, Xingmin
Liu, Baoping
Thyroid stimulating hormone suppression time on cardiac function of patients with differentiated thyroid carcinoma
title Thyroid stimulating hormone suppression time on cardiac function of patients with differentiated thyroid carcinoma
title_full Thyroid stimulating hormone suppression time on cardiac function of patients with differentiated thyroid carcinoma
title_fullStr Thyroid stimulating hormone suppression time on cardiac function of patients with differentiated thyroid carcinoma
title_full_unstemmed Thyroid stimulating hormone suppression time on cardiac function of patients with differentiated thyroid carcinoma
title_short Thyroid stimulating hormone suppression time on cardiac function of patients with differentiated thyroid carcinoma
title_sort thyroid stimulating hormone suppression time on cardiac function of patients with differentiated thyroid carcinoma
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245826/
https://www.ncbi.nlm.nih.gov/pubmed/30479568
http://dx.doi.org/10.1186/s12935-018-0686-9
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