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HEXIM1-Tat chimera inhibits HIV-1 replication

Transcription of HIV provirus is a key step of the viral cycle, and depends on the recruitment of the cellular positive transcription elongation factor b (P-TEFb) to the HIV promoter. The viral transactivator Tat can displace P-TEFb from the 7SK small nuclear ribonucleoprotein, where it is bound and...

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Detalles Bibliográficos
Autores principales:	Leoz, Marie, Kukanja, Petra, Luo, Zeping, Huang, Fang, Cary, Daniele C., Peterlin, B. Matija, Fujinaga, Koh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245832/ https://www.ncbi.nlm.nih.gov/pubmed/30395647 http://dx.doi.org/10.1371/journal.ppat.1007402

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