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A novel non-sulphamoylated 2-methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions

BACKGROUND: 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical application. Therefore, more stable derivatives with potentially improved clinical featur...

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Detalles Bibliográficos
Autores principales:	Botes, Mandie, Jurgens, Tamarin, Riahi, Zohreh, Visagie, Michelle, Janse van Vuuren, Rustelle, Joubert, Anna Margaretha, van den Bout, Iman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245879/ https://www.ncbi.nlm.nih.gov/pubmed/30479567 http://dx.doi.org/10.1186/s12935-018-0688-7

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