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In vitro culture expansion impairs chondrogenic differentiation and the therapeutic effect of mesenchymal stem cells by regulating the unfolded protein response
In vitro expansion of mesenchymal stem cells (MSCs) has been implicated in loss of multipotency, leading to impaired chondrogenic potential and an eventual therapeutic effect, as reported in our previous study. However, the precise regulatory mechanism is still unclear. Here, we demonstrate that end...
Autores principales: | Shen, Chong, Jiang, Tongmeng, Zhu, Bo, Le, Yiguan, Liu, Jianwei, Qin, Zainen, Chen, Haimin, Zhong, Gang, Zheng, Li, Zhao, Jinmin, Zhang, Xingdong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245887/ https://www.ncbi.nlm.nih.gov/pubmed/30479659 http://dx.doi.org/10.1186/s13036-018-0119-2 |
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