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In vitro culture expansion impairs chondrogenic differentiation and the therapeutic effect of mesenchymal stem cells by regulating the unfolded protein response

In vitro expansion of mesenchymal stem cells (MSCs) has been implicated in loss of multipotency, leading to impaired chondrogenic potential and an eventual therapeutic effect, as reported in our previous study. However, the precise regulatory mechanism is still unclear. Here, we demonstrate that end...

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Detalles Bibliográficos
Autores principales:	Shen, Chong, Jiang, Tongmeng, Zhu, Bo, Le, Yiguan, Liu, Jianwei, Qin, Zainen, Chen, Haimin, Zhong, Gang, Zheng, Li, Zhao, Jinmin, Zhang, Xingdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245887/ https://www.ncbi.nlm.nih.gov/pubmed/30479659 http://dx.doi.org/10.1186/s13036-018-0119-2

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