The Histone H3 Lysine 4 Presenter WDR5 as an Oncogenic Protein and Novel Epigenetic Target in Cancer

The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal b...

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Detalles Bibliográficos
Autores principales: Lu, Kebin, Tao, He, Si, Xiaomin, Chen, Qingjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246693/
https://www.ncbi.nlm.nih.gov/pubmed/30488017
http://dx.doi.org/10.3389/fonc.2018.00502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246693/
https://www.ncbi.nlm.nih.gov/pubmed/30488017
http://dx.doi.org/10.3389/fonc.2018.00502

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