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Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer
Regarding TNM staging in breast cancer, T2 category is currently not divided into subcategories even though it covers a wider range of tumor sizes than T1 category. Using Korean Breast Cancer Registry database, data of 41 071 women diagnosed as non‐metastatic T2 breast cancer between 2001 and 2014 w...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246943/ https://www.ncbi.nlm.nih.gov/pubmed/30311421 http://dx.doi.org/10.1002/cam4.1831 |
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author | Jung, Jiwoong Suh, Young Jin Ko, Byung Kyun Lee, Eun Sook Kim, Eun‐Kyu Paik, Nam Sun Byun, Kyung Do Hwang, Ki‐Tae Ahn, Sei Hyun Noh, Dong‐Young Nam, Seok Jin Park, Byeong‐Woo Noh, Woo Chul Yoon, Jung Han Lee, Soo Jung Lee, Eun Kyu Jeong, Joon Han, Sehwan Park, Ho Yong Paik, Nam‐Sun Bae, Young Tae Lee, Hyouk Jin Park, Heung kyu Ko, Seung Sang Park, Woo‐Chan Jung, Sung Hoo Cho, Se Heon Kim, Sei Joong Oh, Se Jeong Kim, Ku Sang Park, Chanheun Song, Byung Joo Kim, Je Ryong Bae, Jeoung Won Kim, Jeong‐Soo Kang, Sun Hee Gwak, Geumhee Lee, Jee Hyun Kim, Tae Hyun Chang, Myungchul Kim, Sung Yong Lee, Jung Sun Song, Jeong‐Yoon Park, Hai Lin Min, Sun Young Yang, Jung‐Hyun Park, Sung Hwan Baek, Jong‐Min Kim, Lee Su Ryu, Dong Won Kim, Kweon Cheon Chung, Min Sung Park, Hee Boong Lim, Cheol Wan Choi, Un Jong Kwak, Beom Seok Park, Young Sam Shin, Hyuk Jai Choi, Young Jin Kim, Doyil Han, Airi Koh, Jong Hyun Choi, Sangyong Yoon, Daesung Choi, Soo Youn Chul, Shin Hee Kim, Jae Il Choi, Jae Hyuck Ryu, Jin Woo Ko, Chang Dae Lee, Il Kyun Lee, Dong Seok Choi, Seunghye Min, Youn Ki Jeon, Young San Park, Eun‐Hwa |
author_facet | Jung, Jiwoong Suh, Young Jin Ko, Byung Kyun Lee, Eun Sook Kim, Eun‐Kyu Paik, Nam Sun Byun, Kyung Do Hwang, Ki‐Tae Ahn, Sei Hyun Noh, Dong‐Young Nam, Seok Jin Park, Byeong‐Woo Noh, Woo Chul Yoon, Jung Han Lee, Soo Jung Lee, Eun Kyu Jeong, Joon Han, Sehwan Park, Ho Yong Paik, Nam‐Sun Bae, Young Tae Lee, Hyouk Jin Park, Heung kyu Ko, Seung Sang Park, Woo‐Chan Jung, Sung Hoo Cho, Se Heon Kim, Sei Joong Oh, Se Jeong Kim, Ku Sang Park, Chanheun Song, Byung Joo Kim, Je Ryong Bae, Jeoung Won Kim, Jeong‐Soo Kang, Sun Hee Gwak, Geumhee Lee, Jee Hyun Kim, Tae Hyun Chang, Myungchul Kim, Sung Yong Lee, Jung Sun Song, Jeong‐Yoon Park, Hai Lin Min, Sun Young Yang, Jung‐Hyun Park, Sung Hwan Baek, Jong‐Min Kim, Lee Su Ryu, Dong Won Kim, Kweon Cheon Chung, Min Sung Park, Hee Boong Lim, Cheol Wan Choi, Un Jong Kwak, Beom Seok Park, Young Sam Shin, Hyuk Jai Choi, Young Jin Kim, Doyil Han, Airi Koh, Jong Hyun Choi, Sangyong Yoon, Daesung Choi, Soo Youn Chul, Shin Hee Kim, Jae Il Choi, Jae Hyuck Ryu, Jin Woo Ko, Chang Dae Lee, Il Kyun Lee, Dong Seok Choi, Seunghye Min, Youn Ki Jeon, Young San Park, Eun‐Hwa |
author_sort | Jung, Jiwoong |
collection | PubMed |
description | Regarding TNM staging in breast cancer, T2 category is currently not divided into subcategories even though it covers a wider range of tumor sizes than T1 category. Using Korean Breast Cancer Registry database, data of 41 071 women diagnosed as non‐metastatic T2 breast cancer between 2001 and 2014 were analyzed. Cutoff value for optimal tumor size was approximated by receiver operating characteristic (ROC) curve to subcategorize T2 tumors. Overall survival (OS) was compared between two subcategories. Median follow‐up period was 65 months. Of 41 071 patients, 4504 (11.0%) died. Based on ROC curve analysis, 3.0 cm was selected as the cutoff value. Five‐year OS rate was 91% in patients with breast tumors ≤3.0 cm (T2a) and 86% in patients with breast tumors >3.0 cm (T2b) (log‐rank P < 0.001). T2b subcategory showed worse OS than T2a subcategory regardless of node status (log‐rank P < 0.001 for all node categories). Within every subgroup defined by primary OS analysis covariates, T2b subcategory consistently showed worse outcome compared to T2a subcategory. By multivariate analysis, T2b subcategory was a significant independent prognostic factor of OS (hazard ratio: 1.26, 95% CI = 1.18‐1.34). T2 category of breast cancer could be subcategorized into T2a and T2b with a cutoff value of 3 cm. These subcategories definitely showed different OSs even after adjusted for known prognostic factors. Subcategorization of T2 category might be useful for predicting prognosis more accurately and tailoring adjuvant therapy. |
format | Online Article Text |
id | pubmed-6246943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62469432018-11-26 Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer Jung, Jiwoong Suh, Young Jin Ko, Byung Kyun Lee, Eun Sook Kim, Eun‐Kyu Paik, Nam Sun Byun, Kyung Do Hwang, Ki‐Tae Ahn, Sei Hyun Noh, Dong‐Young Nam, Seok Jin Park, Byeong‐Woo Noh, Woo Chul Yoon, Jung Han Lee, Soo Jung Lee, Eun Kyu Jeong, Joon Han, Sehwan Park, Ho Yong Paik, Nam‐Sun Bae, Young Tae Lee, Hyouk Jin Park, Heung kyu Ko, Seung Sang Park, Woo‐Chan Jung, Sung Hoo Cho, Se Heon Kim, Sei Joong Oh, Se Jeong Kim, Ku Sang Park, Chanheun Song, Byung Joo Kim, Je Ryong Bae, Jeoung Won Kim, Jeong‐Soo Kang, Sun Hee Gwak, Geumhee Lee, Jee Hyun Kim, Tae Hyun Chang, Myungchul Kim, Sung Yong Lee, Jung Sun Song, Jeong‐Yoon Park, Hai Lin Min, Sun Young Yang, Jung‐Hyun Park, Sung Hwan Baek, Jong‐Min Kim, Lee Su Ryu, Dong Won Kim, Kweon Cheon Chung, Min Sung Park, Hee Boong Lim, Cheol Wan Choi, Un Jong Kwak, Beom Seok Park, Young Sam Shin, Hyuk Jai Choi, Young Jin Kim, Doyil Han, Airi Koh, Jong Hyun Choi, Sangyong Yoon, Daesung Choi, Soo Youn Chul, Shin Hee Kim, Jae Il Choi, Jae Hyuck Ryu, Jin Woo Ko, Chang Dae Lee, Il Kyun Lee, Dong Seok Choi, Seunghye Min, Youn Ki Jeon, Young San Park, Eun‐Hwa Cancer Med Clinical Cancer Research Regarding TNM staging in breast cancer, T2 category is currently not divided into subcategories even though it covers a wider range of tumor sizes than T1 category. Using Korean Breast Cancer Registry database, data of 41 071 women diagnosed as non‐metastatic T2 breast cancer between 2001 and 2014 were analyzed. Cutoff value for optimal tumor size was approximated by receiver operating characteristic (ROC) curve to subcategorize T2 tumors. Overall survival (OS) was compared between two subcategories. Median follow‐up period was 65 months. Of 41 071 patients, 4504 (11.0%) died. Based on ROC curve analysis, 3.0 cm was selected as the cutoff value. Five‐year OS rate was 91% in patients with breast tumors ≤3.0 cm (T2a) and 86% in patients with breast tumors >3.0 cm (T2b) (log‐rank P < 0.001). T2b subcategory showed worse OS than T2a subcategory regardless of node status (log‐rank P < 0.001 for all node categories). Within every subgroup defined by primary OS analysis covariates, T2b subcategory consistently showed worse outcome compared to T2a subcategory. By multivariate analysis, T2b subcategory was a significant independent prognostic factor of OS (hazard ratio: 1.26, 95% CI = 1.18‐1.34). T2 category of breast cancer could be subcategorized into T2a and T2b with a cutoff value of 3 cm. These subcategories definitely showed different OSs even after adjusted for known prognostic factors. Subcategorization of T2 category might be useful for predicting prognosis more accurately and tailoring adjuvant therapy. John Wiley and Sons Inc. 2018-10-12 /pmc/articles/PMC6246943/ /pubmed/30311421 http://dx.doi.org/10.1002/cam4.1831 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Jung, Jiwoong Suh, Young Jin Ko, Byung Kyun Lee, Eun Sook Kim, Eun‐Kyu Paik, Nam Sun Byun, Kyung Do Hwang, Ki‐Tae Ahn, Sei Hyun Noh, Dong‐Young Nam, Seok Jin Park, Byeong‐Woo Noh, Woo Chul Yoon, Jung Han Lee, Soo Jung Lee, Eun Kyu Jeong, Joon Han, Sehwan Park, Ho Yong Paik, Nam‐Sun Bae, Young Tae Lee, Hyouk Jin Park, Heung kyu Ko, Seung Sang Park, Woo‐Chan Jung, Sung Hoo Cho, Se Heon Kim, Sei Joong Oh, Se Jeong Kim, Ku Sang Park, Chanheun Song, Byung Joo Kim, Je Ryong Bae, Jeoung Won Kim, Jeong‐Soo Kang, Sun Hee Gwak, Geumhee Lee, Jee Hyun Kim, Tae Hyun Chang, Myungchul Kim, Sung Yong Lee, Jung Sun Song, Jeong‐Yoon Park, Hai Lin Min, Sun Young Yang, Jung‐Hyun Park, Sung Hwan Baek, Jong‐Min Kim, Lee Su Ryu, Dong Won Kim, Kweon Cheon Chung, Min Sung Park, Hee Boong Lim, Cheol Wan Choi, Un Jong Kwak, Beom Seok Park, Young Sam Shin, Hyuk Jai Choi, Young Jin Kim, Doyil Han, Airi Koh, Jong Hyun Choi, Sangyong Yoon, Daesung Choi, Soo Youn Chul, Shin Hee Kim, Jae Il Choi, Jae Hyuck Ryu, Jin Woo Ko, Chang Dae Lee, Il Kyun Lee, Dong Seok Choi, Seunghye Min, Youn Ki Jeon, Young San Park, Eun‐Hwa Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer |
title | Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer |
title_full | Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer |
title_fullStr | Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer |
title_full_unstemmed | Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer |
title_short | Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer |
title_sort | clinical implication of subcategorizing t2 category into t2a and t2b in tnm staging of breast cancer |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246943/ https://www.ncbi.nlm.nih.gov/pubmed/30311421 http://dx.doi.org/10.1002/cam4.1831 |
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